IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation

IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation

Tuberculosis (TB) is a chronic disease mainly caused by Mycobacterium tuberculosis. The function of T cells usually decreased and even exhausted in severe TB such as multiple drug resistant TB (MDR-TB), which might lead to the failure of treatment in return. The mechanism of T cell dysfunction in TB...

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Bibliographic Details
Main Authors: Xun Liu, Fei Li, Hongxia Niu, Lan Ma, Jianzhu Chen, Ying Zhang, Liang Peng, Chao Gan, Xingming Ma, Bingdong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
T cell exhaustion
T cell dysfunction
antigen persistence
IL-2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02350/full

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