Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study
Abstract Background Hepatic steatosis has a pivotal role in the development of chronic liver diseases, even in alcohol-related liver disease. Alcoholic fatty liver disease is an important phenotype among alcohol-related liver diseases. While metabolic syndrome is a dominant risk factor of incident n...
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doaj-0ee4735d186344519c0e866d4f6e8b212021-08-15T11:18:34ZengBMCBMC Gastroenterology1471-230X2021-08-012111910.1186/s12876-021-01893-4Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA studyYuta Yoshimura0Masahide Hamaguchi1Yoshitaka Hashimoto2Takuro Okamura3Naoko Nakanishi4Akihiro Obora5Takao Kojima6Michiaki Fukui7Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Gastroenterology, Asahi University HospitalDepartment of Gastroenterology, Asahi University HospitalDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of MedicineAbstract Background Hepatic steatosis has a pivotal role in the development of chronic liver diseases, even in alcohol-related liver disease. Alcoholic fatty liver disease is an important phenotype among alcohol-related liver diseases. While metabolic syndrome is a dominant risk factor of incident nonalcoholic fatty liver disease, the role of metabolic syndrome in alcoholic fatty liver disease has not been clarified yet. Methods A retrospective cohort study was performed at a health check-up center in Japan. Subjects consisted of male participants without fatty liver who consumed ethanol of 420 g/week or higher. Adjusted hazard ratios and 95% confidence intervals at the baseline examinations for incident alcoholic fatty liver disease were estimated using Cox model. Results A total of 640 participants were included in this study. During 3.91 years (IQR 1.63–7.09) of follow-up, 168 new cases of alcoholic fatty liver disease developed (49.1 cases per 1000 persons per year). After adjustment for age, smoking status, alcohol consumption, the hazard ratio for a 1 kg/m2 increase in body mass index was 1.2 (1.12–1.28). The hazard ratio of subjects with high triglyceride and low high-density lipoprotein-cholesterol levels were 1.56 (1.12–2.18) and 1.52 (1.03–2.25), respectively. Conclusions Obesity, high triglyceridemia, and low high-density lipoprotein-cholesterolemia are independent risk factors of alcoholic fatty liver disease in Japanese men who consumed alcohol habitually. In people with these risks, triglyceride lowering and high-density lipoprotein-cholesterol raising by improving insulin resistance and weight maintenance in addition to abstinence from alcohol would be effective in preventing the development of alcoholic fatty liver disease.https://doi.org/10.1186/s12876-021-01893-4Alcohol-related liver diseaseFatty liverObesityDyslipidemiaMetabolic syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuta Yoshimura Masahide Hamaguchi Yoshitaka Hashimoto Takuro Okamura Naoko Nakanishi Akihiro Obora Takao Kojima Michiaki Fukui |
spellingShingle |
Yuta Yoshimura Masahide Hamaguchi Yoshitaka Hashimoto Takuro Okamura Naoko Nakanishi Akihiro Obora Takao Kojima Michiaki Fukui Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study BMC Gastroenterology Alcohol-related liver disease Fatty liver Obesity Dyslipidemia Metabolic syndrome |
author_facet |
Yuta Yoshimura Masahide Hamaguchi Yoshitaka Hashimoto Takuro Okamura Naoko Nakanishi Akihiro Obora Takao Kojima Michiaki Fukui |
author_sort |
Yuta Yoshimura |
title |
Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study |
title_short |
Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study |
title_full |
Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study |
title_fullStr |
Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study |
title_full_unstemmed |
Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study |
title_sort |
obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: nagala study |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2021-08-01 |
description |
Abstract Background Hepatic steatosis has a pivotal role in the development of chronic liver diseases, even in alcohol-related liver disease. Alcoholic fatty liver disease is an important phenotype among alcohol-related liver diseases. While metabolic syndrome is a dominant risk factor of incident nonalcoholic fatty liver disease, the role of metabolic syndrome in alcoholic fatty liver disease has not been clarified yet. Methods A retrospective cohort study was performed at a health check-up center in Japan. Subjects consisted of male participants without fatty liver who consumed ethanol of 420 g/week or higher. Adjusted hazard ratios and 95% confidence intervals at the baseline examinations for incident alcoholic fatty liver disease were estimated using Cox model. Results A total of 640 participants were included in this study. During 3.91 years (IQR 1.63–7.09) of follow-up, 168 new cases of alcoholic fatty liver disease developed (49.1 cases per 1000 persons per year). After adjustment for age, smoking status, alcohol consumption, the hazard ratio for a 1 kg/m2 increase in body mass index was 1.2 (1.12–1.28). The hazard ratio of subjects with high triglyceride and low high-density lipoprotein-cholesterol levels were 1.56 (1.12–2.18) and 1.52 (1.03–2.25), respectively. Conclusions Obesity, high triglyceridemia, and low high-density lipoprotein-cholesterolemia are independent risk factors of alcoholic fatty liver disease in Japanese men who consumed alcohol habitually. In people with these risks, triglyceride lowering and high-density lipoprotein-cholesterol raising by improving insulin resistance and weight maintenance in addition to abstinence from alcohol would be effective in preventing the development of alcoholic fatty liver disease. |
topic |
Alcohol-related liver disease Fatty liver Obesity Dyslipidemia Metabolic syndrome |
url |
https://doi.org/10.1186/s12876-021-01893-4 |
work_keys_str_mv |
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