A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy

A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy

We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) f...

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Main Authors: Kristoffer Petersson, Archonteia Kyroudi, Jean Bourhis, Crister Ceberg, Tommy Knöös, François Bochud, Raphaël Moeckli
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Physics and Imaging in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405631617300398
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spelling doaj-0eedd2b8b063452eb6028883f6eb95442020-11-24T21:27:47ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162017-07-0135356A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapyKristoffer Petersson0Archonteia Kyroudi1Jean Bourhis2Crister Ceberg3Tommy Knöös4François Bochud5Raphaël Moeckli6Institute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Radiation Oncology, Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, SwedenDepartment of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, Sweden; Radiation Physics, Skåne University Hospital, Lund University, Lund, SwedenInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, Switzerland; Corresponding author at: Institute of Radiation Physics, Rue du Grand-Pré 1, CH-1007 Lausanne, Switzerland.We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference. Keywords: Pareto, Plan quality, Clinical grading analysis, Prostatehttp://www.sciencedirect.com/science/article/pii/S2405631617300398
collection DOAJ
language English
format Article
sources DOAJ
author Kristoffer Petersson
Archonteia Kyroudi
Jean Bourhis
Crister Ceberg
Tommy Knöös
François Bochud
Raphaël Moeckli
spellingShingle Kristoffer Petersson
Archonteia Kyroudi
Jean Bourhis
Crister Ceberg
Tommy Knöös
François Bochud
Raphaël Moeckli
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
Physics and Imaging in Radiation Oncology
author_facet Kristoffer Petersson
Archonteia Kyroudi
Jean Bourhis
Crister Ceberg
Tommy Knöös
François Bochud
Raphaël Moeckli
author_sort Kristoffer Petersson
title A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
title_short A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
title_full A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
title_fullStr A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
title_full_unstemmed A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
title_sort clinical distance measure for evaluating treatment plan quality difference with pareto fronts in radiotherapy
publisher Elsevier
series Physics and Imaging in Radiation Oncology
issn 2405-6316
publishDate 2017-07-01
description We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference. Keywords: Pareto, Plan quality, Clinical grading analysis, Prostate
url http://www.sciencedirect.com/science/article/pii/S2405631617300398
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