A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) f...
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doaj-0eedd2b8b063452eb6028883f6eb95442020-11-24T21:27:47ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162017-07-0135356A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapyKristoffer Petersson0Archonteia Kyroudi1Jean Bourhis2Crister Ceberg3Tommy Knöös4François Bochud5Raphaël Moeckli6Institute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Radiation Oncology, Lausanne University Hospital, Lausanne, SwitzerlandDepartment of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, SwedenDepartment of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Lund, Sweden; Radiation Physics, Skåne University Hospital, Lund University, Lund, SwedenInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, Switzerland; Corresponding author at: Institute of Radiation Physics, Rue du Grand-Pré 1, CH-1007 Lausanne, Switzerland.We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference. Keywords: Pareto, Plan quality, Clinical grading analysis, Prostatehttp://www.sciencedirect.com/science/article/pii/S2405631617300398 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kristoffer Petersson Archonteia Kyroudi Jean Bourhis Crister Ceberg Tommy Knöös François Bochud Raphaël Moeckli |
spellingShingle |
Kristoffer Petersson Archonteia Kyroudi Jean Bourhis Crister Ceberg Tommy Knöös François Bochud Raphaël Moeckli A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy Physics and Imaging in Radiation Oncology |
author_facet |
Kristoffer Petersson Archonteia Kyroudi Jean Bourhis Crister Ceberg Tommy Knöös François Bochud Raphaël Moeckli |
author_sort |
Kristoffer Petersson |
title |
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy |
title_short |
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy |
title_full |
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy |
title_fullStr |
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy |
title_full_unstemmed |
A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy |
title_sort |
clinical distance measure for evaluating treatment plan quality difference with pareto fronts in radiotherapy |
publisher |
Elsevier |
series |
Physics and Imaging in Radiation Oncology |
issn |
2405-6316 |
publishDate |
2017-07-01 |
description |
We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference. Keywords: Pareto, Plan quality, Clinical grading analysis, Prostate |
url |
http://www.sciencedirect.com/science/article/pii/S2405631617300398 |
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