Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates

The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl...

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Bibliographic Details
Main Authors: Brigita Vigante, Martins Rucins, Aiva Plotniece, Karlis Pajuste, Iveta Luntena, Brigita Cekavicus, Egils Bisenieks, Rufus Smits, Gunars Duburs, Arkadij Sobolev
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
1,4-dihydropyridines
ethoxycarbonylmethyl esters
aminolysis
carbamoylmethyl esters
secondary amines
cyclic amines
1,5,7-triazabicyclo[4.4.0]dec-5-ene
Online Access:http://www.mdpi.com/1420-3049/20/11/19697

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