Candida auris: Disinfectants and Implications for Infection Control
Candida auris is a rapidly emerging pathogen and is able to cause severe infections with high mortality rates. It is frequently misidentified in most clinical laboratories, thus requiring more specialized identification techniques. Furthermore, several clinical isolates have been found to be multidr...
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doaj-0eeedc89d0e44be78e573eb8437326e12020-11-25T00:14:23ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-04-01910.3389/fmicb.2018.00726357170Candida auris: Disinfectants and Implications for Infection ControlTsun S. N. Ku0Tsun S. N. Ku1Carla J. Walraven2Samuel A. Lee3Samuel A. Lee4Section of Infectious Disease, New Mexico VA Health Care System, Albuquerque, NM, United StatesDivision of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, United StatesCollege of Pharmacy, University of New Mexico Health Science Center, Albuquerque, NM, United StatesSection of Infectious Disease, New Mexico VA Health Care System, Albuquerque, NM, United StatesDivision of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, United StatesCandida auris is a rapidly emerging pathogen and is able to cause severe infections with high mortality rates. It is frequently misidentified in most clinical laboratories, thus requiring more specialized identification techniques. Furthermore, several clinical isolates have been found to be multidrug resistant and there is evidence of nosocomial transmission in outbreak fashion. Appropriate infection control measures will play a major role in controlling the management and spread of this pathogen. Unfortunately, there are very few data available on the effectiveness of disinfectants against C. auris. Chlorine-based products appear to be the most effective for environmental surface disinfection. Other disinfectants, although less effective than chlorine-based products, may have a role as adjunctive disinfectants. A cleaning protocol will also need to be established as the use of disinfectants alone may not be sufficient for maximal decontamination of patient care areas. Furthermore, there are fewer data on the effectiveness of antiseptics against C. auris for patient decolonization and hand hygiene for healthcare personnel. Chlorhexidine gluconate has shown some efficacy in in vitro studies but there are reports of patients with persistent colonization despite twice daily body washes with this disinfectant. Hand hygiene using soap and water, with or without chlorhexidine gluconate, may require the subsequent use of alcohol-based hand sanitizer for maximal disinfection. Further studies will be needed to validate the currently studied disinfectants for use in real-world settings.http://journal.frontiersin.org/article/10.3389/fmicb.2018.00726/fullCandida aurisdisinfectantsantisepticsbiocidesinfection controldecolonization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tsun S. N. Ku Tsun S. N. Ku Carla J. Walraven Samuel A. Lee Samuel A. Lee |
spellingShingle |
Tsun S. N. Ku Tsun S. N. Ku Carla J. Walraven Samuel A. Lee Samuel A. Lee Candida auris: Disinfectants and Implications for Infection Control Frontiers in Microbiology Candida auris disinfectants antiseptics biocides infection control decolonization |
author_facet |
Tsun S. N. Ku Tsun S. N. Ku Carla J. Walraven Samuel A. Lee Samuel A. Lee |
author_sort |
Tsun S. N. Ku |
title |
Candida auris: Disinfectants and Implications for Infection Control |
title_short |
Candida auris: Disinfectants and Implications for Infection Control |
title_full |
Candida auris: Disinfectants and Implications for Infection Control |
title_fullStr |
Candida auris: Disinfectants and Implications for Infection Control |
title_full_unstemmed |
Candida auris: Disinfectants and Implications for Infection Control |
title_sort |
candida auris: disinfectants and implications for infection control |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2018-04-01 |
description |
Candida auris is a rapidly emerging pathogen and is able to cause severe infections with high mortality rates. It is frequently misidentified in most clinical laboratories, thus requiring more specialized identification techniques. Furthermore, several clinical isolates have been found to be multidrug resistant and there is evidence of nosocomial transmission in outbreak fashion. Appropriate infection control measures will play a major role in controlling the management and spread of this pathogen. Unfortunately, there are very few data available on the effectiveness of disinfectants against C. auris. Chlorine-based products appear to be the most effective for environmental surface disinfection. Other disinfectants, although less effective than chlorine-based products, may have a role as adjunctive disinfectants. A cleaning protocol will also need to be established as the use of disinfectants alone may not be sufficient for maximal decontamination of patient care areas. Furthermore, there are fewer data on the effectiveness of antiseptics against C. auris for patient decolonization and hand hygiene for healthcare personnel. Chlorhexidine gluconate has shown some efficacy in in vitro studies but there are reports of patients with persistent colonization despite twice daily body washes with this disinfectant. Hand hygiene using soap and water, with or without chlorhexidine gluconate, may require the subsequent use of alcohol-based hand sanitizer for maximal disinfection. Further studies will be needed to validate the currently studied disinfectants for use in real-world settings. |
topic |
Candida auris disinfectants antiseptics biocides infection control decolonization |
url |
http://journal.frontiersin.org/article/10.3389/fmicb.2018.00726/full |
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