Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease
Parkinson’s disease is a neurological disorder characterized by the manifestation of motor symptoms, such as akinesia, muscle rigidity and tremor at rest. These symptoms are classically attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra (SNc), which results i...
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doaj-0ef01c39a5b24381b8d8a9d91ff932c02020-11-25T00:22:44ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-05-01610.3389/fnagi.2014.0008796240Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s diseaseAbdelhamid eBenazzouz0Omar eMamad1Omar eMamad2Pamphyle eAbedi3Pamphyle eAbedi4Rabia eBouali-Benazzouz5Jonathan eChetrit6Univ. de BordeauxUniv. de BordeauxUniversity Mohamed V-AgdalUniv. de BordeauxUniversity Mohamed V-AgdalBordeaux UniversityUniv. de BordeauxParkinson’s disease is a neurological disorder characterized by the manifestation of motor symptoms, such as akinesia, muscle rigidity and tremor at rest. These symptoms are classically attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra (SNc), which results in a marked dopamine depletion in the striatum. It is well established that dopamine neurons in the SNc innervate not only the striatum, which is the main target, but also other basal ganglia nuclei including the two segments of globus pallidus and the subthalamic nucleus. The role of dopamine and its depletion in the striatum is well known, however, the role of dopamine depletion in the pallidal complex and the subthalamic nucleus in the genesis of their abnormal neuronal activity and in parkinsonian motor deficits is still not clearly determined. Based on recent experimental data from animal models of Parkinson's disease in rodents and non-human primates and also from parkinsonian patients, this review summarizes current knowledge on the role of dopamine in the modulation of basal ganglia neuronal activity and also the role of dopamine depletion in these nuclei in the pathophysiology of Parkinson's disease.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00087/fullBasal GangliaDopamineGlobus PallidusSubthalamic NucleusParkinson’s diseaseExtrastriatal dopamine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdelhamid eBenazzouz Omar eMamad Omar eMamad Pamphyle eAbedi Pamphyle eAbedi Rabia eBouali-Benazzouz Jonathan eChetrit |
spellingShingle |
Abdelhamid eBenazzouz Omar eMamad Omar eMamad Pamphyle eAbedi Pamphyle eAbedi Rabia eBouali-Benazzouz Jonathan eChetrit Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease Frontiers in Aging Neuroscience Basal Ganglia Dopamine Globus Pallidus Subthalamic Nucleus Parkinson’s disease Extrastriatal dopamine |
author_facet |
Abdelhamid eBenazzouz Omar eMamad Omar eMamad Pamphyle eAbedi Pamphyle eAbedi Rabia eBouali-Benazzouz Jonathan eChetrit |
author_sort |
Abdelhamid eBenazzouz |
title |
Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease |
title_short |
Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease |
title_full |
Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease |
title_fullStr |
Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease |
title_full_unstemmed |
Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson’s disease |
title_sort |
involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2014-05-01 |
description |
Parkinson’s disease is a neurological disorder characterized by the manifestation of motor symptoms, such as akinesia, muscle rigidity and tremor at rest. These symptoms are classically attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra (SNc), which results in a marked dopamine depletion in the striatum. It is well established that dopamine neurons in the SNc innervate not only the striatum, which is the main target, but also other basal ganglia nuclei including the two segments of globus pallidus and the subthalamic nucleus. The role of dopamine and its depletion in the striatum is well known, however, the role of dopamine depletion in the pallidal complex and the subthalamic nucleus in the genesis of their abnormal neuronal activity and in parkinsonian motor deficits is still not clearly determined. Based on recent experimental data from animal models of Parkinson's disease in rodents and non-human primates and also from parkinsonian patients, this review summarizes current knowledge on the role of dopamine in the modulation of basal ganglia neuronal activity and also the role of dopamine depletion in these nuclei in the pathophysiology of Parkinson's disease. |
topic |
Basal Ganglia Dopamine Globus Pallidus Subthalamic Nucleus Parkinson’s disease Extrastriatal dopamine |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00087/full |
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