Systematic Review of Human and Animal Studies Examining the Efficacy and Safety of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) in Traumatic Brain Injury: Impact on Neurofunctional Outcome and Biomarkers of Oxidative Stress and Inflammation

Systematic Review of Human and Animal Studies Examining the Efficacy and Safety of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) in Traumatic Brain Injury: Impact on Neurofunctional Outcome and Biomarkers of Oxidative Stress and Inflammation

BackgroundNo new therapies for traumatic brain injury (TBI) have been officially translated into current practice. At the tissue and cellular level, both inflammatory and oxidative processes may be exacerbated post-injury and contribute to further brain damage. N-acetylcysteine (NAC) has the potenti...

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Bibliographic Details
Main Authors: Junaid Bhatti, Barto Nascimento, Umbreen Akhtar, Shawn G. Rhind, Homer Tien, Avery Nathens, Luis Teodoro da Luz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Neurology
Subjects:
N-acetylcysteine
N-acetylcysteine amide
traumatic brain injury
neurofunctional outcome
animal models
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00744/full

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