Lkb1 maintains Treg cell lineage identity
The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune di...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15876 |
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doaj-0ef92e5f9d09435488a06a64dac0a2a32021-05-11T07:17:05ZengNature Publishing GroupNature Communications2041-17232017-06-018111410.1038/ncomms15876Lkb1 maintains Treg cell lineage identityDi Wu0Yuechen Luo1Wei Guo2Qing Niu3Ting Xue4Fei Yang5Xiaolei Sun6Song Chen7Yuanyuan Liu8Jingru Liu9Zhina Sun10Chunxiao Zhao11Huifang Huang12Fang Liao13Zhongchao Han14Dongming Zhou15Yongguang Yang16Guogang Xu17Tao Cheng18Xiaoming Feng19State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Medical Microbiology, Tongji Medical College, Huazhong University of Science and TechnologyState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeCentral Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan RoadState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeCentral Laboratory, The Union Hospital of Fujian Medical University, 29 Xinquan RoadDepartment of Medical Microbiology, Tongji Medical College, Huazhong University of Science and TechnologyState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeInstitute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesFirst Hospital of Jilin UniversityNanlou Respiratory Department, Chinese PLA General HospitalState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical CollegeThe protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.https://doi.org/10.1038/ncomms15876 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng |
| spellingShingle |
Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng Lkb1 maintains Treg cell lineage identity Nature Communications |
| author_facet |
Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng |
| author_sort |
Di Wu |
| title |
Lkb1 maintains Treg cell lineage identity |
| title_short |
Lkb1 maintains Treg cell lineage identity |
| title_full |
Lkb1 maintains Treg cell lineage identity |
| title_fullStr |
Lkb1 maintains Treg cell lineage identity |
| title_full_unstemmed |
Lkb1 maintains Treg cell lineage identity |
| title_sort |
lkb1 maintains treg cell lineage identity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-06-01 |
| description |
The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease. |
| url |
https://doi.org/10.1038/ncomms15876 |
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