Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice
Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood press...
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doaj-0f03552d90d1406a908af9d8c1945f2e2020-11-24T23:25:26ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942015-01-01201510.1155/2015/467471467471Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in MiceHilda Vargas-Robles0Amelia Rios1Monica Arellano-Mendoza2Bruno A. Escalante3Michael Schnoor4Department for Molecular Biomedicine, Center of Research and Advanced Studies (CINVESTAV) of the National Polytechnic Institute (IPN), Zacatenco, 07360 Mexico City, DF, MexicoCINVESTAV-IPN Monterrey, 66600 Apodaca, NL, MexicoSuperior Medical School, IPN, Postgraduate and Research Section, 11340 Mexico City, DF, MexicoCINVESTAV-IPN Monterrey, 66600 Apodaca, NL, MexicoDepartment for Molecular Biomedicine, Center of Research and Advanced Studies (CINVESTAV) of the National Polytechnic Institute (IPN), Zacatenco, 07360 Mexico City, DF, MexicoObesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.http://dx.doi.org/10.1155/2015/467471 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hilda Vargas-Robles Amelia Rios Monica Arellano-Mendoza Bruno A. Escalante Michael Schnoor |
spellingShingle |
Hilda Vargas-Robles Amelia Rios Monica Arellano-Mendoza Bruno A. Escalante Michael Schnoor Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice Oxidative Medicine and Cellular Longevity |
author_facet |
Hilda Vargas-Robles Amelia Rios Monica Arellano-Mendoza Bruno A. Escalante Michael Schnoor |
author_sort |
Hilda Vargas-Robles |
title |
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice |
title_short |
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice |
title_full |
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice |
title_fullStr |
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice |
title_full_unstemmed |
Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice |
title_sort |
antioxidative diet supplementation reverses high-fat diet-induced increases of cardiovascular risk factors in mice |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2015-01-01 |
description |
Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications. |
url |
http://dx.doi.org/10.1155/2015/467471 |
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