Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models
Parkinson’s disease: restoring mitochondrial function in disease models A peptide targeting mitochondria can help deliver an antioxidant protein to mitigate the effects of Parkinson’s disease in cellular and mouse models. Youngmi Pak from Kyung Hee University, Seoul, South Korea, and co-workers engi...
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2018-08-01
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Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-018-0124-z |
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doaj-0f057882b63c40fe8fa2447f5367b29b2020-12-08T13:51:57ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-08-0150811310.1038/s12276-018-0124-zCell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease modelsYoung Cheol Kang0Minuk Son1Sora Kang2Suyeol Im3Ying Piao4Kwang Suk Lim5Min-Young Song6Kang-Sik Park7Yong-Hee Kim8Youngmi Kim Pak9Department of Neuroscience, Graduate School, Kyung Hee UniversityDepartment of Neuroscience, Graduate School, Kyung Hee UniversityDepartment of Neuroscience, Graduate School, Kyung Hee UniversityDepartment of Neuroscience, Graduate School, Kyung Hee UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Physiology, College of Medicine, Kyung Hee UniversityDepartment of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang UniversityDepartment of Neuroscience, Graduate School, Kyung Hee UniversityParkinson’s disease: restoring mitochondrial function in disease models A peptide targeting mitochondria can help deliver an antioxidant protein to mitigate the effects of Parkinson’s disease in cellular and mouse models. Youngmi Pak from Kyung Hee University, Seoul, South Korea, and co-workers engineered bacteria to express the human version of an antioxidant protein called metallothionein 1A fused to a short peptide sequence so that it localizes to mitochondria, the cellular power plants. Once inside the mitochondria, the peptide is removed, leaving the mature antioxidant protein to mop up damaging free radicals, a common problem seen in the cells of patients with Parkinson’s disease, and restore mitochondria to a healthier state. The protein improved mitochondrial function in both a human cell line and in the neurons of mice with a Parkinson’s-like disease, suggesting it might also help patients with this devastating neurological condition.https://doi.org/10.1038/s12276-018-0124-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young Cheol Kang Minuk Son Sora Kang Suyeol Im Ying Piao Kwang Suk Lim Min-Young Song Kang-Sik Park Yong-Hee Kim Youngmi Kim Pak |
spellingShingle |
Young Cheol Kang Minuk Son Sora Kang Suyeol Im Ying Piao Kwang Suk Lim Min-Young Song Kang-Sik Park Yong-Hee Kim Youngmi Kim Pak Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models Experimental and Molecular Medicine |
author_facet |
Young Cheol Kang Minuk Son Sora Kang Suyeol Im Ying Piao Kwang Suk Lim Min-Young Song Kang-Sik Park Yong-Hee Kim Youngmi Kim Pak |
author_sort |
Young Cheol Kang |
title |
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models |
title_short |
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models |
title_full |
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models |
title_fullStr |
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models |
title_full_unstemmed |
Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models |
title_sort |
cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1a alleviates mitochondrial damage in parkinson’s disease models |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
2092-6413 |
publishDate |
2018-08-01 |
description |
Parkinson’s disease: restoring mitochondrial function in disease models A peptide targeting mitochondria can help deliver an antioxidant protein to mitigate the effects of Parkinson’s disease in cellular and mouse models. Youngmi Pak from Kyung Hee University, Seoul, South Korea, and co-workers engineered bacteria to express the human version of an antioxidant protein called metallothionein 1A fused to a short peptide sequence so that it localizes to mitochondria, the cellular power plants. Once inside the mitochondria, the peptide is removed, leaving the mature antioxidant protein to mop up damaging free radicals, a common problem seen in the cells of patients with Parkinson’s disease, and restore mitochondria to a healthier state. The protein improved mitochondrial function in both a human cell line and in the neurons of mice with a Parkinson’s-like disease, suggesting it might also help patients with this devastating neurological condition. |
url |
https://doi.org/10.1038/s12276-018-0124-z |
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