Distinct and evolutionary conserved structural features of the human nuclear exosome complex

Distinct and evolutionary conserved structural features of the human nuclear exosome complex

The nuclear RNA exosome complex mediates the processing of structured RNAs and the decay of aberrant non-coding RNAs, an important function particularly in human cells. Most mechanistic studies to date have focused on the yeast system. Here, we reconstituted and studied the properties of a recombina...

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Bibliographic Details
Main Authors: Piotr Gerlach, Jan M Schuller, Fabien Bonneau, Jérôme Basquin, Peter Reichelt, Sebastian Falk, Elena Conti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
nuclear exosome
RNA decay
cryoEM
hEXO-14
hDIS3
hMTR4
Online Access:https://elifesciences.org/articles/38686

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