The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience
Infection-related glomerulonephritis (IRGN) is an example of immunological renal injury due to non-renal infections. With the changing face of IRGN over the years, renal biopsy definitely has an important role to play in differentiating this disease from the other masquerades and helps in prognostic...
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doaj-0f0dfdbc2e084d5ba4927a68dea3949a2020-11-24T22:49:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Nephrology0971-40651998-36622017-01-0127430731210.4103/ijn.IJN_280_16The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experienceM TrivediA PasariA R ChowdhuryA A KurienR PandeyInfection-related glomerulonephritis (IRGN) is an example of immunological renal injury due to non-renal infections. With the changing face of IRGN over the years, renal biopsy definitely has an important role to play in differentiating this disease from the other masquerades and helps in prognosticating the long-term outcomes. This prospective study includes biopsy-proven IRGN cases who presented to us from July 2010 to July 2013 from a single center in East India. Of the 168 patients suspected and screened, 137 patients were proved to have IRGN. About 11.67% cases were proven to be immunoglobulin A-IRGN variant. The mean age of presentation was 22.7 ± 15.8 years with a slight male preponderance. A nephrotic range of proteinuria was seen in 13.8% cases and 17.5% patient required renal replacement therapy at presentation. Around 8.75% patients had persistent proteinuria despite normal renal function beyond 6 months of follow-up and 8.09% patients progressed to chronic kidney disease. It may no longer be classified as a glomerular disease with the definite favorable outcome as an important number of patients may progress to chronicity following this disease. Renal biopsy plays an important role in the assessment of prognosis of IRGN and detection of the presence of other underlying glomerulonephritis and should be considered early, especially in patients with atypical presentation.http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2017;volume=27;issue=4;spage=307;epage=312;aulast=TrivediImmunoglobulin A-infection-related glomerulonephritisIndiainfection-related glomerulonephritispostinfectious glomerulonephritisrenal biopsy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M Trivedi A Pasari A R Chowdhury A A Kurien R Pandey |
spellingShingle |
M Trivedi A Pasari A R Chowdhury A A Kurien R Pandey The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience Indian Journal of Nephrology Immunoglobulin A-infection-related glomerulonephritis India infection-related glomerulonephritis postinfectious glomerulonephritis renal biopsy |
author_facet |
M Trivedi A Pasari A R Chowdhury A A Kurien R Pandey |
author_sort |
M Trivedi |
title |
The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience |
title_short |
The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience |
title_full |
The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience |
title_fullStr |
The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience |
title_full_unstemmed |
The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: A single center experience |
title_sort |
epidemiology, clinical features, and outcome of infection-related glomerulonephritis from east india: a single center experience |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Nephrology |
issn |
0971-4065 1998-3662 |
publishDate |
2017-01-01 |
description |
Infection-related glomerulonephritis (IRGN) is an example of immunological renal injury due to non-renal infections. With the changing face of IRGN over the years, renal biopsy definitely has an important role to play in differentiating this disease from the other masquerades and helps in prognosticating the long-term outcomes. This prospective study includes biopsy-proven IRGN cases who presented to us from July 2010 to July 2013 from a single center in East India. Of the 168 patients suspected and screened, 137 patients were proved to have IRGN. About 11.67% cases were proven to be immunoglobulin A-IRGN variant. The mean age of presentation was 22.7 ± 15.8 years with a slight male preponderance. A nephrotic range of proteinuria was seen in 13.8% cases and 17.5% patient required renal replacement therapy at presentation. Around 8.75% patients had persistent proteinuria despite normal renal function beyond 6 months of follow-up and 8.09% patients progressed to chronic kidney disease. It may no longer be classified as a glomerular disease with the definite favorable outcome as an important number of patients may progress to chronicity following this disease. Renal biopsy plays an important role in the assessment of prognosis of IRGN and detection of the presence of other underlying glomerulonephritis and should be considered early, especially in patients with atypical presentation. |
topic |
Immunoglobulin A-infection-related glomerulonephritis India infection-related glomerulonephritis postinfectious glomerulonephritis renal biopsy |
url |
http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2017;volume=27;issue=4;spage=307;epage=312;aulast=Trivedi |
work_keys_str_mv |
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