JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review
Abstract The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals. The spectrum of underlying reasons for the systemic immunosuppression tha...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-07-01
|
Series: | AIDS Research and Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12981-020-00293-0 |
id |
doaj-0f0e327818d2491995d082ad6ef1d1e1 |
---|---|
record_format |
Article |
spelling |
doaj-0f0e327818d2491995d082ad6ef1d1e12020-11-25T03:52:30ZengBMCAIDS Research and Therapy1742-64052020-07-0117111110.1186/s12981-020-00293-0JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a reviewVijay Harypursat0Yihong Zhou1Shengquan Tang2Yaokai Chen3Division of Infectious Diseases, Chongqing Public Health Medical CenterDivision of Infectious Diseases, Chongqing Public Health Medical CenterDivision of Infectious Diseases, Chongqing Public Health Medical CenterDivision of Infectious Diseases, Chongqing Public Health Medical CenterAbstract The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals. The spectrum of underlying reasons for the systemic immunosuppression that permits JCV infection in the central nervous system has evolved over the past 2 decades, and therapeutic immunosuppression arousing JCV infection in the brain has become increasingly prominent as a trigger for PML. Effective immune restoration subsequent to human immunodeficiency virus-related suppression is now recognized as a cause for unexpected deterioration of symptoms in patients with PML, secondary to a rebound inflammatory phenomenon called immune reconstitution inflammatory syndrome, resulting in significantly increased morbidity and mortality in a disease already infamous for its lethality. This review addresses current knowledge regarding JC Polyomavirus, progressive multifocal leukoencephalopathy, progressive multifocal leukoencephalopathy-related immune reconstitution inflammatory syndrome, and the immunocompromised states that incite JC Polyomavirus central nervous system infection, and discusses prospects for the future management of these conditions.http://link.springer.com/article/10.1186/s12981-020-00293-0ImmunosuppressionOligodendrocyteMonoclonal antibodiesImmunocompromised state |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vijay Harypursat Yihong Zhou Shengquan Tang Yaokai Chen |
spellingShingle |
Vijay Harypursat Yihong Zhou Shengquan Tang Yaokai Chen JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review AIDS Research and Therapy Immunosuppression Oligodendrocyte Monoclonal antibodies Immunocompromised state |
author_facet |
Vijay Harypursat Yihong Zhou Shengquan Tang Yaokai Chen |
author_sort |
Vijay Harypursat |
title |
JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
title_short |
JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
title_full |
JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
title_fullStr |
JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
title_full_unstemmed |
JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
title_sort |
jc polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review |
publisher |
BMC |
series |
AIDS Research and Therapy |
issn |
1742-6405 |
publishDate |
2020-07-01 |
description |
Abstract The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals. The spectrum of underlying reasons for the systemic immunosuppression that permits JCV infection in the central nervous system has evolved over the past 2 decades, and therapeutic immunosuppression arousing JCV infection in the brain has become increasingly prominent as a trigger for PML. Effective immune restoration subsequent to human immunodeficiency virus-related suppression is now recognized as a cause for unexpected deterioration of symptoms in patients with PML, secondary to a rebound inflammatory phenomenon called immune reconstitution inflammatory syndrome, resulting in significantly increased morbidity and mortality in a disease already infamous for its lethality. This review addresses current knowledge regarding JC Polyomavirus, progressive multifocal leukoencephalopathy, progressive multifocal leukoencephalopathy-related immune reconstitution inflammatory syndrome, and the immunocompromised states that incite JC Polyomavirus central nervous system infection, and discusses prospects for the future management of these conditions. |
topic |
Immunosuppression Oligodendrocyte Monoclonal antibodies Immunocompromised state |
url |
http://link.springer.com/article/10.1186/s12981-020-00293-0 |
work_keys_str_mv |
AT vijayharypursat jcpolyomavirusprogressivemultifocalleukoencephalopathyandimmunereconstitutioninflammatorysyndromeareview AT yihongzhou jcpolyomavirusprogressivemultifocalleukoencephalopathyandimmunereconstitutioninflammatorysyndromeareview AT shengquantang jcpolyomavirusprogressivemultifocalleukoencephalopathyandimmunereconstitutioninflammatorysyndromeareview AT yaokaichen jcpolyomavirusprogressivemultifocalleukoencephalopathyandimmunereconstitutioninflammatorysyndromeareview |
_version_ |
1724482496706379776 |