Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
There is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapy
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Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09601-3 |
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doaj-0f16c669a80d42d6a657840c444b1b4e2021-05-11T12:02:20ZengNature Publishing GroupNature Communications2041-17232019-04-0110111210.1038/s41467-019-09601-3Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammationJun Zheng0Rong Fan1Huiqiong Wu2Honghui Yao3Yujie Yan4Jiamiao Liu5Lu Ran6Zhifang Sun7Lunzhao Yi8Li Dang9Pingping Gan10Piao Zheng11Tilong Yang12Yi Zhang13Tao Tang14Yang Wang15Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South UniversityInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South UniversityKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South UniversityXiangya School of Medicine, Central South UniversityXiangya School of Medicine, Central South UniversityXiangya School of Medicine, Central South UniversityYunnan Food Safety Research Institute, Kunming University of Science and TechnologyKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South UniversityYunnan Food Safety Research Institute, Kunming University of Science and TechnologyDepartment of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityCollege of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese MedicineSouthern University of Science and TechnologyKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South UniversityInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South UniversityInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South UniversityThere is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapyhttps://doi.org/10.1038/s41467-019-09601-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jun Zheng Rong Fan Huiqiong Wu Honghui Yao Yujie Yan Jiamiao Liu Lu Ran Zhifang Sun Lunzhao Yi Li Dang Pingping Gan Piao Zheng Tilong Yang Yi Zhang Tao Tang Yang Wang |
| spellingShingle |
Jun Zheng Rong Fan Huiqiong Wu Honghui Yao Yujie Yan Jiamiao Liu Lu Ran Zhifang Sun Lunzhao Yi Li Dang Pingping Gan Piao Zheng Tilong Yang Yi Zhang Tao Tang Yang Wang Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation Nature Communications |
| author_facet |
Jun Zheng Rong Fan Huiqiong Wu Honghui Yao Yujie Yan Jiamiao Liu Lu Ran Zhifang Sun Lunzhao Yi Li Dang Pingping Gan Piao Zheng Tilong Yang Yi Zhang Tao Tang Yang Wang |
| author_sort |
Jun Zheng |
| title |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| title_short |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| title_full |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| title_fullStr |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| title_full_unstemmed |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| title_sort |
directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
There is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapy |
| url |
https://doi.org/10.1038/s41467-019-09601-3 |
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