Mechanism of Warburg Effect and Its Effect on Tumor Metastasis

Mechanism of Warburg Effect and Its Effect on Tumor Metastasis

Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear, recent works indicated that it might be rela...

Full description

Bibliographic Details
Main Authors: Huijun WEI, Lili GUO, Lin LI, Qinghua ZHOU, Zhihao WU
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2015-03-01
Series:Chinese Journal of Lung Cancer
Subjects:
Warburg effect
Mechanism
Tumor metastasis
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2015.03.09
id doaj-0f1d0ece4a804c21b5b09eead7566117
record_format Article
spelling doaj-0f1d0ece4a804c21b5b09eead75661172020-11-24T23:28:23ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34192015-03-0118317918310.3779/j.issn.1009-3419.2015.03.09Mechanism of Warburg Effect and Its Effect on Tumor MetastasisHuijun WEI0Lili GUO1Lin LI2Qinghua ZHOU3Zhihao WU4Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaCancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear, recent works indicated that it might be related to the abnormal activity of the oncogene and tumor suppressor genes, also the change of tumor microenvironment, the abnormal expression of glucose metabolic enzyme and so on. Warburg effect has a relationship with tumor progression and provide suitable conditions for tumor metastasis. This review will summarizes the mechanism of Warburg effect and its effect on tumor metastasis.http://dx.doi.org/10.3779/j.issn.1009-3419.2015.03.09Warburg effectMechanismTumor metastasis
collection DOAJ
language zho
format Article
sources DOAJ
author Huijun WEI
Lili GUO
Lin LI
Qinghua ZHOU
Zhihao WU
spellingShingle Huijun WEI
Lili GUO
Lin LI
Qinghua ZHOU
Zhihao WU
Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
Chinese Journal of Lung Cancer
Warburg effect
Mechanism
Tumor metastasis
author_facet Huijun WEI
Lili GUO
Lin LI
Qinghua ZHOU
Zhihao WU
author_sort Huijun WEI
title Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
title_short Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
title_full Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
title_fullStr Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
title_full_unstemmed Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
title_sort mechanism of warburg effect and its effect on tumor metastasis
publisher Chinese Anti-Cancer Association; Chinese Antituberculosis Association
series Chinese Journal of Lung Cancer
issn 1009-3419
publishDate 2015-03-01
description Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear, recent works indicated that it might be related to the abnormal activity of the oncogene and tumor suppressor genes, also the change of tumor microenvironment, the abnormal expression of glucose metabolic enzyme and so on. Warburg effect has a relationship with tumor progression and provide suitable conditions for tumor metastasis. This review will summarizes the mechanism of Warburg effect and its effect on tumor metastasis.
topic Warburg effect
Mechanism
Tumor metastasis
url http://dx.doi.org/10.3779/j.issn.1009-3419.2015.03.09
work_keys_str_mv AT huijunwei mechanismofwarburgeffectanditseffectontumormetastasis
AT liliguo mechanismofwarburgeffectanditseffectontumormetastasis
AT linli mechanismofwarburgeffectanditseffectontumormetastasis
AT qinghuazhou mechanismofwarburgeffectanditseffectontumormetastasis
AT zhihaowu mechanismofwarburgeffectanditseffectontumormetastasis
_version_ 1725549391790473216

Similar Items