Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation
Most cases of strongyloidiasis associated with solid organ transplantation have been due to the reactivation of a latent infection in the recipient as a result of the immunosuppressive therapy; however, donor-derived infections are becoming increasingly frequent. The case of a patient who nearly die...
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doaj-0f2033e8a31d46bf956f49d6853a61072020-11-24T23:22:32ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-10-0151C192110.1016/j.ijid.2016.08.014Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantationA. Galiano0M. Trelis1Á. Moya-Herráiz2J. Sánchez-Plumed3J.F. Merino4Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, SpainDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, SpainHepatobiliopancreatic Surgery and Transplantation Unit, Department of General Surgery, La Fe University and Polytechnic Hospital, Valencia, SpainDepartment of Nephrology, La Fe University and Polytechnic Hospital, Valencia, SpainJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, Valencia, SpainMost cases of strongyloidiasis associated with solid organ transplantation have been due to the reactivation of a latent infection in the recipient as a result of the immunosuppressive therapy; however, donor-derived infections are becoming increasingly frequent. The case of a patient who nearly died of a Strongyloides stercoralis hyperinfection after receiving simultaneous kidney/pancreas transplants is described herein. No specific parasitological tests were performed pre-transplantation, despite the fact that both the recipient and the donor originated from endemic areas. Serological analysis of the donor's serum performed retrospectively revealed the origin of the infection, which if it had been done beforehand would have prevented the serious complications. Current practice guidelines need to be updated to incorporate immunological and molecular techniques for the rapid screening of Strongyloides prior to transplantation, and empirical treatment with ivermectin should be applied systematically when there is the slightest risk of infection in the donor or recipient.http://www.sciencedirect.com/science/article/pii/S1201971216311419StrongyloidesHyperinfectionDonor-derivedTransplantPancreasKidney |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Galiano M. Trelis Á. Moya-Herráiz J. Sánchez-Plumed J.F. Merino |
spellingShingle |
A. Galiano M. Trelis Á. Moya-Herráiz J. Sánchez-Plumed J.F. Merino Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation International Journal of Infectious Diseases Strongyloides Hyperinfection Donor-derived Transplant Pancreas Kidney |
author_facet |
A. Galiano M. Trelis Á. Moya-Herráiz J. Sánchez-Plumed J.F. Merino |
author_sort |
A. Galiano |
title |
Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
title_short |
Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
title_full |
Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
title_fullStr |
Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
title_full_unstemmed |
Donor-derived Strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
title_sort |
donor-derived strongyloides stercoralis hyperinfection syndrome after simultaneous kidney/pancreas transplantation |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2016-10-01 |
description |
Most cases of strongyloidiasis associated with solid organ transplantation have been due to the reactivation of a latent infection in the recipient as a result of the immunosuppressive therapy; however, donor-derived infections are becoming increasingly frequent. The case of a patient who nearly died of a Strongyloides stercoralis hyperinfection after receiving simultaneous kidney/pancreas transplants is described herein. No specific parasitological tests were performed pre-transplantation, despite the fact that both the recipient and the donor originated from endemic areas. Serological analysis of the donor's serum performed retrospectively revealed the origin of the infection, which if it had been done beforehand would have prevented the serious complications. Current practice guidelines need to be updated to incorporate immunological and molecular techniques for the rapid screening of Strongyloides prior to transplantation, and empirical treatment with ivermectin should be applied systematically when there is the slightest risk of infection in the donor or recipient. |
topic |
Strongyloides Hyperinfection Donor-derived Transplant Pancreas Kidney |
url |
http://www.sciencedirect.com/science/article/pii/S1201971216311419 |
work_keys_str_mv |
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