Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing evidences that RT-activated Sirpα-deficient ma...

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Bibliographic Details
Main Authors: Zhen Bian, Lei Shi, Koby Kidder, Ke Zen, Charlie Garnett-Benson, Yuan Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23442-z
Description
Summary:Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing evidences that RT-activated Sirpα-deficient macrophages promote T-cell mediated anti-tumor immune responses.
ISSN:2041-1723

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