EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty
Abstract Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced u...
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Online Access: | https://doi.org/10.1002/cam4.3295 |
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doaj-0f27b3fa6d4149258596423d4f6402d32020-11-25T03:06:40ZengWileyCancer Medicine2045-76342020-11-019218074808510.1002/cam4.3295EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertaintyAugustin Le Naour0Adrien Rossary1Marie‐Paule Vasson2UMR 1019 Human Nutrition Unit, ECREIN team University of Clermont Auvergne, INRAE, CRNH‐Auvergne Clermont‐Ferrand FranceUMR 1019 Human Nutrition Unit, ECREIN team University of Clermont Auvergne, INRAE, CRNH‐Auvergne Clermont‐Ferrand FranceUMR 1019 Human Nutrition Unit, ECREIN team University of Clermont Auvergne, INRAE, CRNH‐Auvergne Clermont‐Ferrand FranceAbstract Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced under different names: EO771, EO 771, and E0771. The characteristics of the EO771 cells are well described but some data are contradictory. This cell line presents the great interest of developing an immunocompetent neoplastic model using an orthotopic implantation reflecting the mammary tumors encountered in breast cancer patients. This review presents the phenotype characteristics of EO771 and its sensitivity to nutrients and different therapies such as radiotherapy, chemotherapy, hormone therapy, and immunotherapy.https://doi.org/10.1002/cam4.3295antineoplastic agentsbreast neoplasmshormonal receptorsmicemurine cell lineinbred C57BL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Augustin Le Naour Adrien Rossary Marie‐Paule Vasson |
spellingShingle |
Augustin Le Naour Adrien Rossary Marie‐Paule Vasson EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty Cancer Medicine antineoplastic agents breast neoplasms hormonal receptors mice murine cell line inbred C57BL |
author_facet |
Augustin Le Naour Adrien Rossary Marie‐Paule Vasson |
author_sort |
Augustin Le Naour |
title |
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty |
title_short |
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty |
title_full |
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty |
title_fullStr |
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty |
title_full_unstemmed |
EO771, is it a well‐characterized cell line for mouse mammary cancer model? Limit and uncertainty |
title_sort |
eo771, is it a well‐characterized cell line for mouse mammary cancer model? limit and uncertainty |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2020-11-01 |
description |
Abstract Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced under different names: EO771, EO 771, and E0771. The characteristics of the EO771 cells are well described but some data are contradictory. This cell line presents the great interest of developing an immunocompetent neoplastic model using an orthotopic implantation reflecting the mammary tumors encountered in breast cancer patients. This review presents the phenotype characteristics of EO771 and its sensitivity to nutrients and different therapies such as radiotherapy, chemotherapy, hormone therapy, and immunotherapy. |
topic |
antineoplastic agents breast neoplasms hormonal receptors mice murine cell line inbred C57BL |
url |
https://doi.org/10.1002/cam4.3295 |
work_keys_str_mv |
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