$Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene$

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.

Bibliographic Details
Main Authors:	Carolin Seuring, Kartik Ayyer, Eleftheria Filippaki, Miriam Barthelmess, Jean-Nicolas Longchamp, Philippe Ringler, Tommaso Pardini, David H. Wojtas, Matthew A. Coleman, Katerina Dörner, Silje Fuglerud, Greger Hammarin, Birgit Habenstein, Annette E. Langkilde, Antoine Loquet, Alke Meents, Roland Riek, Henning Stahlberg, Sébastien Boutet, Mark S. Hunter, Jason Koglin, Mengning Liang, Helen M. Ginn, Rick P. Millane, Matthias Frank, Anton Barty, Henry N. Chapman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04116-9

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spelling	doaj-0f29de3d658a4701815f6d96e5366ab42021-05-11T10:16:39ZengNature Publishing GroupNature Communications2041-17232018-05-019111010.1038/s41467-018-04116-9Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background grapheneCarolin Seuring0Kartik Ayyer1Eleftheria Filippaki2Miriam Barthelmess3Jean-Nicolas Longchamp4Philippe Ringler5Tommaso Pardini6David H. Wojtas7Matthew A. Coleman8Katerina Dörner9Silje Fuglerud10Greger Hammarin11Birgit Habenstein12Annette E. Langkilde13Antoine Loquet14Alke Meents15Roland Riek16Henning Stahlberg17Sébastien Boutet18Mark S. Hunter19Jason Koglin20Mengning Liang21Helen M. Ginn22Rick P. Millane23Matthias Frank24Anton Barty25Henry N. Chapman26Center for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronPhysics Department of the University of ZurichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselLawrence Livermore National LaboratoryDepartment of Electrical and Computer Engineering, University of CanterburyLawrence Livermore National LaboratoryCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronDepartment of Chemistry and Molecular BiologyCNRS, CBMN UMR5248, IECB, Université de BordeauxDepartment of Drug Design and Pharmacology, University of CopenhagenCNRS, CBMN UMR5248, IECB, Université de BordeauxCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronLaboratory of Physical Chemistry, ETH ZürichCenter for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of BaselLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryLinac Coherent Light Source, SLAC National Accelerator LaboratoryDivision of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of OxfordDepartment of Electrical and Computer Engineering, University of CanterburyLawrence Livermore National LaboratoryCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronCenter for Free-Electron Laser Science, Deutsches Elektronen-SynchrotronThe structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.https://doi.org/10.1038/s41467-018-04116-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman
spellingShingle	Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene Nature Communications
author_facet	Carolin Seuring Kartik Ayyer Eleftheria Filippaki Miriam Barthelmess Jean-Nicolas Longchamp Philippe Ringler Tommaso Pardini David H. Wojtas Matthew A. Coleman Katerina Dörner Silje Fuglerud Greger Hammarin Birgit Habenstein Annette E. Langkilde Antoine Loquet Alke Meents Roland Riek Henning Stahlberg Sébastien Boutet Mark S. Hunter Jason Koglin Mengning Liang Helen M. Ginn Rick P. Millane Matthias Frank Anton Barty Henry N. Chapman
author_sort	Carolin Seuring
title	Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
title_short	Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
title_full	Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
title_fullStr	Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
title_full_unstemmed	Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
title_sort	femtosecond x-ray coherent diffraction of aligned amyloid fibrils on low background graphene
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.
url	https://doi.org/10.1038/s41467-018-04116-9
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Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

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