Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells
Abstract.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, increase ABCA1 mRNA levels in hepatoma cell lines, bu...
Main Authors: | Takashi Maejima, Tomohiro Sugano, Hiroyuki Yamazaki, Yasunobu Yoshinaka, Takeshi Doi, Sohei Tanabe, Tomoko Nishimaki-Mogami |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2011-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319307273 |
Similar Items
-
Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma.
by: K Y Hostetler, et al.
Published: (1979-07-01) -
Altered subcellular and submitochondrial localization of CTP:phosphatidate cytidylyltransferase in the Morris 7777 hepatoma.
by: K Y Hostetler, et al.
Published: (1978-07-01) -
Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
by: Fuichi Yap, Lauren Craddock, Jian Yang
Published: (2011-01-01) -
Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
by: Shunxing Rong, et al.
Published: (2017-02-01) -
Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia
by: Jianhua Li, et al.
Published: (2016-01-01)