Vasoconstrictor Mechanisms in Chronic Hypoxia-Induced Pulmonary Hypertension: Role of Oxidant Signaling

Elevated resistance of pulmonary circulation after chronic hypoxia exposure leads to pulmonary hypertension. Contributing to this pathological process is enhanced pulmonary vasoconstriction through both calcium-dependent and calcium sensitization mechanisms. Reactive oxygen species (ROS), as a resul...

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Bibliographic Details
Main Authors: Simin Yan, Thomas C. Resta, Nikki L. Jernigan
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/9/10/999

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