Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator?
<b> </b>In this article, construction of amperometric sensor(s) based on screen-printed carbon electrodes covered by thin layers of two types of carbon nanomaterials serving as amplifiers, and containing [Cu(bipy)<sub>2</sub>Cl]Cl∙5H<sub>2</sub>O complex is report...
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MDPI AG
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/1/113 |
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doaj-0f36aa9e35f24b9798cb79bb33a06b222020-12-30T00:04:30ZengMDPI AGMaterials1996-19442021-12-011411311310.3390/ma14010113Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator?Milan Sýs0Atripan Mukherjee1Granit Jashari2Vojtěch Adam3Amir M. Ashrafi4Miroslav Novák5Lukáš Richtera6Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech RepublicDepartment of Chemistry and Biochemistry, Mendel University in Brno, CZ-613 00 Brno, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech RepublicDepartment of Chemistry and Biochemistry, Mendel University in Brno, CZ-613 00 Brno, Czech RepublicDepartment of Chemistry and Biochemistry, Mendel University in Brno, CZ-613 00 Brno, Czech RepublicInstitute of Chemistry and Technology of Macromolecular Materials, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech RepublicDepartment of Chemistry and Biochemistry, Mendel University in Brno, CZ-613 00 Brno, Czech Republic<b> </b>In this article, construction of amperometric sensor(s) based on screen-printed carbon electrodes covered by thin layers of two types of carbon nanomaterials serving as amplifiers, and containing [Cu(bipy)<sub>2</sub>Cl]Cl∙5H<sub>2</sub>O complex is reported. Their performance and biomimetic activity towards two selected neurotransmitters (dopamine and serotonin) was studied mainly using flow injection analysis (FIA). The important parameters of FIA such as working potential, flow rate, and pH were optimized. The mechanism of the catalytic activity is explained and experimentally confirmed. It reveals that presence of hydrogen peroxide plays a crucial role which leads to answer the title question: can presented complex really be considered as a tyrosinase biomimetic catalyst or only as a redox mediator?https://www.mdpi.com/1996-1944/14/1/113electrochemical biomimetic devicesbis(2,2′-bipyridil)copper(II) chloride complexflow injection analysisneurotransmitters |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Milan Sýs Atripan Mukherjee Granit Jashari Vojtěch Adam Amir M. Ashrafi Miroslav Novák Lukáš Richtera |
| spellingShingle |
Milan Sýs Atripan Mukherjee Granit Jashari Vojtěch Adam Amir M. Ashrafi Miroslav Novák Lukáš Richtera Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? Materials electrochemical biomimetic devices bis(2,2′-bipyridil)copper(II) chloride complex flow injection analysis neurotransmitters |
| author_facet |
Milan Sýs Atripan Mukherjee Granit Jashari Vojtěch Adam Amir M. Ashrafi Miroslav Novák Lukáš Richtera |
| author_sort |
Milan Sýs |
| title |
Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? |
| title_short |
Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? |
| title_full |
Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? |
| title_fullStr |
Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? |
| title_full_unstemmed |
Bis(2,2′-bipyridil)Copper(II) Chloride Complex: Tyrosinase Biomimetic Catalyst or Redox Mediator? |
| title_sort |
bis(2,2′-bipyridil)copper(ii) chloride complex: tyrosinase biomimetic catalyst or redox mediator? |
| publisher |
MDPI AG |
| series |
Materials |
| issn |
1996-1944 |
| publishDate |
2021-12-01 |
| description |
<b> </b>In this article, construction of amperometric sensor(s) based on screen-printed carbon electrodes covered by thin layers of two types of carbon nanomaterials serving as amplifiers, and containing [Cu(bipy)<sub>2</sub>Cl]Cl∙5H<sub>2</sub>O complex is reported. Their performance and biomimetic activity towards two selected neurotransmitters (dopamine and serotonin) was studied mainly using flow injection analysis (FIA). The important parameters of FIA such as working potential, flow rate, and pH were optimized. The mechanism of the catalytic activity is explained and experimentally confirmed. It reveals that presence of hydrogen peroxide plays a crucial role which leads to answer the title question: can presented complex really be considered as a tyrosinase biomimetic catalyst or only as a redox mediator? |
| topic |
electrochemical biomimetic devices bis(2,2′-bipyridil)copper(II) chloride complex flow injection analysis neurotransmitters |
| url |
https://www.mdpi.com/1996-1944/14/1/113 |
| work_keys_str_mv |
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| _version_ |
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