TRP Channels as Therapeutic Targets in Diabetes and Obesity
During the last three to four decades the prevalence of obesity and diabetes mellitus has greatly increased worldwide, including in the United States. Both the short- and long-term forecasts predict serious consequences for the near future, and encourage the development of solutions for the preventi...
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doaj-0f45bd1d9d304dccba258b9a317b11902020-11-25T01:46:33ZengMDPI AGPharmaceuticals1424-82472016-08-01935010.3390/ph9030050ph9030050TRP Channels as Therapeutic Targets in Diabetes and ObesityAndrea Zsombok0Andrei V. Derbenev1Department of Physiology, School of Medicine, Tulane University, New Orleans, LA 70112, USADepartment of Physiology, School of Medicine, Tulane University, New Orleans, LA 70112, USADuring the last three to four decades the prevalence of obesity and diabetes mellitus has greatly increased worldwide, including in the United States. Both the short- and long-term forecasts predict serious consequences for the near future, and encourage the development of solutions for the prevention and management of obesity and diabetes mellitus. Transient receptor potential (TRP) channels were identified in tissues and organs important for the control of whole body metabolism. A variety of TRP channels has been shown to play a role in the regulation of hormone release, energy expenditure, pancreatic function, and neurotransmitter release in control, obese and/or diabetic conditions. Moreover, dietary supplementation of natural ligands of TRP channels has been shown to have potential beneficial effects in obese and diabetic conditions. These findings raised the interest and likelihood for potential drug development. In this mini-review, we discuss possibilities for better management of obesity and diabetes mellitus based on TRP-dependent mechanisms.http://www.mdpi.com/1424-8247/9/3/50TRPV1TRPMTRPA1obesitydiabetes mellitusmetabolismglucose homeostasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Zsombok Andrei V. Derbenev |
spellingShingle |
Andrea Zsombok Andrei V. Derbenev TRP Channels as Therapeutic Targets in Diabetes and Obesity Pharmaceuticals TRPV1 TRPM TRPA1 obesity diabetes mellitus metabolism glucose homeostasis |
author_facet |
Andrea Zsombok Andrei V. Derbenev |
author_sort |
Andrea Zsombok |
title |
TRP Channels as Therapeutic Targets in Diabetes and Obesity |
title_short |
TRP Channels as Therapeutic Targets in Diabetes and Obesity |
title_full |
TRP Channels as Therapeutic Targets in Diabetes and Obesity |
title_fullStr |
TRP Channels as Therapeutic Targets in Diabetes and Obesity |
title_full_unstemmed |
TRP Channels as Therapeutic Targets in Diabetes and Obesity |
title_sort |
trp channels as therapeutic targets in diabetes and obesity |
publisher |
MDPI AG |
series |
Pharmaceuticals |
issn |
1424-8247 |
publishDate |
2016-08-01 |
description |
During the last three to four decades the prevalence of obesity and diabetes mellitus has greatly increased worldwide, including in the United States. Both the short- and long-term forecasts predict serious consequences for the near future, and encourage the development of solutions for the prevention and management of obesity and diabetes mellitus. Transient receptor potential (TRP) channels were identified in tissues and organs important for the control of whole body metabolism. A variety of TRP channels has been shown to play a role in the regulation of hormone release, energy expenditure, pancreatic function, and neurotransmitter release in control, obese and/or diabetic conditions. Moreover, dietary supplementation of natural ligands of TRP channels has been shown to have potential beneficial effects in obese and diabetic conditions. These findings raised the interest and likelihood for potential drug development. In this mini-review, we discuss possibilities for better management of obesity and diabetes mellitus based on TRP-dependent mechanisms. |
topic |
TRPV1 TRPM TRPA1 obesity diabetes mellitus metabolism glucose homeostasis |
url |
http://www.mdpi.com/1424-8247/9/3/50 |
work_keys_str_mv |
AT andreazsombok trpchannelsastherapeutictargetsindiabetesandobesity AT andreivderbenev trpchannelsastherapeutictargetsindiabetesandobesity |
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1725018709935783936 |