Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage

Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage

CD200 is known as an immune checkpoint molecule that inhibits innate immune cell activation. Using a head and neck squamous cell carcinoma (HNSCC) model, we sought to determine whether localized delivery of adenovirus-expressing sCD200R1-Ig, the soluble extracellular domain of CD200R1, enhances anti...

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Bibliographic Details
Main Authors: Seung-Phil Shin, A-Ra Goh, Ji-Min Ju, Hyeon-Gu Kang, Seok-Jun Kim, Jong-Kwang Kim, Eun-Jung Park, Yong-Soo Bae, Kyungho Choi, Yuh-Seog Jung, Sang-Jin Lee
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
CD200
β-catenin
NF-κB
PD-L1
M-CSF
M2-like macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001285

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