Attenuating effects of clenbuterol, β2-agonist, on immobilization - induced atrophy of rat hindlimb muscle fibers

• Main Authors: Hideki Suzuki, Takashi Kitaura
• Format: Article
• Language: English
• Published: Japanese Society of Physical Fitness and Sports Medicine 2015-12-01
• Series: Journal of Physical Fitness and Sports Medicine
• Subjects: clenbuterol; immobilization; hindlimb muscle; atrophy; β2-agonist; attenuating effects
• Online Access: https://www.jstage.jst.go.jp/article/jpfsm/4/5/4_363/_pdf/-char/en

In this review, we discuss the morphologic influence of clenbuterol on muscle atrophy with particular focus on cast-immobilization used in surgical care. β2-agonists induce muscle hypertrophy, particularly in fast muscles. Similar to these anabolic actions, the β2-agonist clenbuterol attenuates immobilization-induced atrophy in fast muscles. Furthermore, the attenuating effects of this agonist on muscle atrophy may be related to its preventative effect in fast muscle fibers.