Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression i...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12960-6 |