GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
Influenza in humans is often accompanied by gastroenteritis-like symptoms. GeGen QinLian decoction (GQD), a Chinese herb formula, has been widely used to treat infectious diarrhea for centuries and has the effect of restoring intestinal flora. Studies have also reported that GQD were used to treat p...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-09-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332221006788 |
id |
doaj-0f6106542a5241408351f54e7f680777 |
---|---|
record_format |
Article |
spelling |
doaj-0f6106542a5241408351f54e7f6807772021-09-05T04:39:08ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-09-01141111896GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal floraLi Deng0Yucong Shi1Pei Liu2Sizhi Wu3Yiwen Lv4Huachong Xu5Xiaoyin Chen6College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCorresponding authors.; College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaCorresponding authors.; College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, ChinaInfluenza in humans is often accompanied by gastroenteritis-like symptoms. GeGen QinLian decoction (GQD), a Chinese herb formula, has been widely used to treat infectious diarrhea for centuries and has the effect of restoring intestinal flora. Studies have also reported that GQD were used to treat patients with influenza. However, whether regulating the intestinal flora is one of the ways GQD treats influenza has not been confirmed. In present research, we conducted a systemic pharmacological study, and the results showed that GQD may acts through multiple targets and pathways. In influenza-infected mice, GQD treatment reduced mortality and lung inflammation. Most importantly, the mortality and lung inflammation were also reduced in influenza-infected mice that have undergone fecal microbiota transplantation (FMT) from GQD (FMT-GQD) treated mice. GQD treatment or FMT-GQD treatment restores the intestinal flora, resulting in an increase in Akkermansia_muciniphila, Desulfovibrio_C21_c20 and Lactobacillus_salivarius, and a decrease in Escherichia_coli. FMT-GQD treatment inhibited the NOD/RIP2/NF-κB signaling pathway in the intestine and affected the expression of downstream related inflammatory cytokines in mesenteric lymph nodes (mLNs) and serum. In addition, FMT-GQD treatment showed systemic protection by restraining the inflammatory differentiation of CD4+ T cells. In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.http://www.sciencedirect.com/science/article/pii/S0753332221006788GeGen QinLian decoctionInfluenza virusIntestinal floraTraditional Chinese Medicine (TCM)NOD (nucleotide-binding and oligomerization domain) and leucine rich repeat containing receptor (NLR) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen |
spellingShingle |
Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora Biomedicine & Pharmacotherapy GeGen QinLian decoction Influenza virus Intestinal flora Traditional Chinese Medicine (TCM) NOD (nucleotide-binding and oligomerization domain) and leucine rich repeat containing receptor (NLR) |
author_facet |
Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen |
author_sort |
Li Deng |
title |
GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
title_short |
GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
title_full |
GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
title_fullStr |
GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
title_full_unstemmed |
GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
title_sort |
gegen qinlian decoction alleviate influenza virus infectious pneumonia through intestinal flora |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2021-09-01 |
description |
Influenza in humans is often accompanied by gastroenteritis-like symptoms. GeGen QinLian decoction (GQD), a Chinese herb formula, has been widely used to treat infectious diarrhea for centuries and has the effect of restoring intestinal flora. Studies have also reported that GQD were used to treat patients with influenza. However, whether regulating the intestinal flora is one of the ways GQD treats influenza has not been confirmed. In present research, we conducted a systemic pharmacological study, and the results showed that GQD may acts through multiple targets and pathways. In influenza-infected mice, GQD treatment reduced mortality and lung inflammation. Most importantly, the mortality and lung inflammation were also reduced in influenza-infected mice that have undergone fecal microbiota transplantation (FMT) from GQD (FMT-GQD) treated mice. GQD treatment or FMT-GQD treatment restores the intestinal flora, resulting in an increase in Akkermansia_muciniphila, Desulfovibrio_C21_c20 and Lactobacillus_salivarius, and a decrease in Escherichia_coli. FMT-GQD treatment inhibited the NOD/RIP2/NF-κB signaling pathway in the intestine and affected the expression of downstream related inflammatory cytokines in mesenteric lymph nodes (mLNs) and serum. In addition, FMT-GQD treatment showed systemic protection by restraining the inflammatory differentiation of CD4+ T cells. In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia. |
topic |
GeGen QinLian decoction Influenza virus Intestinal flora Traditional Chinese Medicine (TCM) NOD (nucleotide-binding and oligomerization domain) and leucine rich repeat containing receptor (NLR) |
url |
http://www.sciencedirect.com/science/article/pii/S0753332221006788 |
work_keys_str_mv |
AT lideng gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT yucongshi gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT peiliu gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT sizhiwu gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT yiwenlv gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT huachongxu gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora AT xiaoyinchen gegenqinliandecoctionalleviateinfluenzavirusinfectiouspneumoniathroughintestinalflora |
_version_ |
1717814608862904320 |