MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.
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2019-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-13598-0 |
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doaj-0f7e8fe68c21423b8d3fab8d3d749d852021-05-11T11:27:50ZengNature Publishing GroupNature Communications2041-17232019-12-0110111710.1038/s41467-019-13598-0MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiationYu Zhao0Jiajian Zhou1Liangqiang He2Yuying Li3Jie Yuan4Kun Sun5Xiaona Chen6Xichen Bao7Miguel A. Esteban8Hao Sun9Huating Wang10Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongLaboratory of RNA Molecular Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesLaboratory of Chromatin and Human Disease, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongEnhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.https://doi.org/10.1038/s41467-019-13598-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang |
spellingShingle |
Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation Nature Communications |
author_facet |
Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang |
author_sort |
Yu Zhao |
title |
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation |
title_short |
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation |
title_full |
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation |
title_fullStr |
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation |
title_full_unstemmed |
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation |
title_sort |
myod induced enhancer rna interacts with hnrnpl to activate target gene transcription during myogenic differentiation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-12-01 |
description |
Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation. |
url |
https://doi.org/10.1038/s41467-019-13598-0 |
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