MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.

Bibliographic Details
Main Authors:	Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A. Esteban, Hao Sun, Huating Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13598-0

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spelling	doaj-0f7e8fe68c21423b8d3fab8d3d749d852021-05-11T11:27:50ZengNature Publishing GroupNature Communications2041-17232019-12-0110111710.1038/s41467-019-13598-0MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiationYu Zhao0Jiajian Zhou1Liangqiang He2Yuying Li3Jie Yuan4Kun Sun5Xiaona Chen6Xichen Bao7Miguel A. Esteban8Hao Sun9Huating Wang10Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongLaboratory of RNA Molecular Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesLaboratory of Chromatin and Human Disease, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongEnhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.https://doi.org/10.1038/s41467-019-13598-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang
spellingShingle	Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation Nature Communications
author_facet	Yu Zhao Jiajian Zhou Liangqiang He Yuying Li Jie Yuan Kun Sun Xiaona Chen Xichen Bao Miguel A. Esteban Hao Sun Huating Wang
author_sort	Yu Zhao
title	MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_short	MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_full	MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_fullStr	MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_full_unstemmed	MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_sort	myod induced enhancer rna interacts with hnrnpl to activate target gene transcription during myogenic differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.
url	https://doi.org/10.1038/s41467-019-13598-0
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MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

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