The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India
Between 2006 and 2010, in 16 randomly selected villages in rural areas of Mysore district, in south India, 8,457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8,457 subjects, 1,692 were randomly invited for further evaluation of lung function and chroni...
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doaj-0f7ed5d4e41c4c5bafa59292b09a3c1c2020-11-25T00:02:14ZengKorean Society of Epidemiology Epidemiology and Health2092-71932018-06-014010.4178/epih.e2018027980The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), IndiaPadukudru Anand Mahesh0Komarla Sundararaja Lokesh1Purnima Madhivanan2Sindaghatta Krishnarao Chaya3Biligere Siddaiah Jayaraj4Koustav Ganguly5Murali Krishna6 Department of Pulmonary Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India Department of Pulmonary Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India Department of Epidemiology, Florida International University, Miami, FL, USA Department of Pulmonary Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India Department of Pulmonary Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Foundation for Research and Advocacy in Mental Health, Mysuru, IndiaBetween 2006 and 2010, in 16 randomly selected villages in rural areas of Mysore district, in south India, 8,457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8,457 subjects, 1,692 were randomly invited for further evaluation of lung function and chronic obstructive pulmonary disease (COPD) by spirometry, and 1,085 of these subjects underwent lung function assessments for prevalent COPD and its risk factors. These 1,085 subjects, who were then aged between 35 and 80 years, constituted the Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA) cohort. Among other findings, threshold of biomass fuel smoke exposure suitable for use as a dichotomous risk factor for the diagnosis of chronic bronchitis was established, with a minimum biomass smoke exposure index of 60 found to be significantly associated with an elevated risk of developing chronic bronchitis. Five years later (between 2014 and 2016), 869 of the 1,085 participants were followed up with repeat lung function assessments for incident COPD and all-cause mortality. A subset of these participants (n=200) underwent blood tests for vitamin D levels, antioxidant activity, an assessment for anxiety and depression, and another subset (n=98) underwent a bioplex assay for 40 serum cytokines.http://www.e-epih.org/upload/pdf/epih-40-e2018027.pdfLung diseasesChronic obstructive pulmonary diseaseAsthmaSpirometryBiomassSmoking |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Padukudru Anand Mahesh Komarla Sundararaja Lokesh Purnima Madhivanan Sindaghatta Krishnarao Chaya Biligere Siddaiah Jayaraj Koustav Ganguly Murali Krishna |
spellingShingle |
Padukudru Anand Mahesh Komarla Sundararaja Lokesh Purnima Madhivanan Sindaghatta Krishnarao Chaya Biligere Siddaiah Jayaraj Koustav Ganguly Murali Krishna The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India Epidemiology and Health Lung diseases Chronic obstructive pulmonary disease Asthma Spirometry Biomass Smoking |
author_facet |
Padukudru Anand Mahesh Komarla Sundararaja Lokesh Purnima Madhivanan Sindaghatta Krishnarao Chaya Biligere Siddaiah Jayaraj Koustav Ganguly Murali Krishna |
author_sort |
Padukudru Anand Mahesh |
title |
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India |
title_short |
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India |
title_full |
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India |
title_fullStr |
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India |
title_full_unstemmed |
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India |
title_sort |
mysuru studies of determinants of health in rural adults (mudhra), india |
publisher |
Korean Society of Epidemiology |
series |
Epidemiology and Health |
issn |
2092-7193 |
publishDate |
2018-06-01 |
description |
Between 2006 and 2010, in 16 randomly selected villages in rural areas of Mysore district, in south India, 8,457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8,457 subjects, 1,692 were randomly invited for further evaluation of lung function and chronic obstructive pulmonary disease (COPD) by spirometry, and 1,085 of these subjects underwent lung function assessments for prevalent COPD and its risk factors. These 1,085 subjects, who were then aged between 35 and 80 years, constituted the Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA) cohort. Among other findings, threshold of biomass fuel smoke exposure suitable for use as a dichotomous risk factor for the diagnosis of chronic bronchitis was established, with a minimum biomass smoke exposure index of 60 found to be significantly associated with an elevated risk of developing chronic bronchitis. Five years later (between 2014 and 2016), 869 of the 1,085 participants were followed up with repeat lung function assessments for incident COPD and all-cause mortality. A subset of these participants (n=200) underwent blood tests for vitamin D levels, antioxidant activity, an assessment for anxiety and depression, and another subset (n=98) underwent a bioplex assay for 40 serum cytokines. |
topic |
Lung diseases Chronic obstructive pulmonary disease Asthma Spirometry Biomass Smoking |
url |
http://www.e-epih.org/upload/pdf/epih-40-e2018027.pdf |
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