A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with P...
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Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06862-2 |
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doaj-0f866c6231f8431bafdb3689de1442992021-05-11T10:04:13ZengNature Publishing GroupNature Communications2041-17232018-10-019111710.1038/s41467-018-06862-2A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastomaMaolei Zhang0Kun Zhao1Xiaoping Xu2Yibing Yang3Sheng Yan4Ping Wei5Hui Liu6Jianbo Xu7Feizhe Xiao8Huangkai Zhou9Xuesong Yang10Nunu Huang11Jinglei Liu12Kejun He13Keping Xie14Gong Zhang15Suyun Huang16Nu Zhang17Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Pathology, Fudan University Shanghai Cancer Center, Fudan UniversityDepartment of Spine Surgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Gastroenterology Surgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Scientific Research Section, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Gastroenterology, University of Texas MD Anderson Cancer CenterInstitute of Life and Health Engineering, College of Life Science and Technology, Jinan UniversityDepartment of Neurosurgery, University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, First Affiliated Hospital of Sun Yat-sen UniversityFunctional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.https://doi.org/10.1038/s41467-018-06862-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maolei Zhang Kun Zhao Xiaoping Xu Yibing Yang Sheng Yan Ping Wei Hui Liu Jianbo Xu Feizhe Xiao Huangkai Zhou Xuesong Yang Nunu Huang Jinglei Liu Kejun He Keping Xie Gong Zhang Suyun Huang Nu Zhang |
| spellingShingle |
Maolei Zhang Kun Zhao Xiaoping Xu Yibing Yang Sheng Yan Ping Wei Hui Liu Jianbo Xu Feizhe Xiao Huangkai Zhou Xuesong Yang Nunu Huang Jinglei Liu Kejun He Keping Xie Gong Zhang Suyun Huang Nu Zhang A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma Nature Communications |
| author_facet |
Maolei Zhang Kun Zhao Xiaoping Xu Yibing Yang Sheng Yan Ping Wei Hui Liu Jianbo Xu Feizhe Xiao Huangkai Zhou Xuesong Yang Nunu Huang Jinglei Liu Kejun He Keping Xie Gong Zhang Suyun Huang Nu Zhang |
| author_sort |
Maolei Zhang |
| title |
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma |
| title_short |
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma |
| title_full |
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma |
| title_fullStr |
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma |
| title_full_unstemmed |
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma |
| title_sort |
peptide encoded by circular form of linc-pint suppresses oncogenic transcriptional elongation in glioblastoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes. |
| url |
https://doi.org/10.1038/s41467-018-06862-2 |
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