Health-Related Quality of Life in Children With Congenital Hyperinsulinism

• Main Authors: Jonna M. E. Männistö, Jarmo Jääskeläinen, Hanna Huopio
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-10-01
• Series: Frontiers in Endocrinology
• Subjects: hypoglycemia; children and adolescent; KINDL-R®; persistent hyperinsulinemic hypoglycemia; transient hyperinsulinism
• Online Access: https://www.frontiersin.org/article/10.3389/fendo.2019.00670/full

Background: Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI).Objectives: To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI.Methods: We studied HRQoL of 65 children with CHI aged 3–17 years (60% males) recruited from the nationwide CHI registry. The median ages were 9.6 (range 3.5–16.3) and 7.4 (3.1–17.9) years in persistent (P-CHI, n = 33) and transient (T-CHI, n = 32) CHI groups, respectively. HRQoL was examined by generic KINDL-R questionnaire and the scores were compared to the age- and gender-specific reference values.Results: In self-reports of subjects aged 11–17 years and in parent reports of children aged 3–17 years, P-CHI or T-CHI children did not have statistically lower scores in any of the six dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school) or in total scores compared to the reference values.Conclusions: CHI is not associated with low HRQoL in childhood or adolescence.