Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia
Background: Chikungunya virus (CHIKV) infection has similar clinical presentations to malaria. Hence, febrile illnesses are often misdiagnosed as malaria. Therefore, this study aimed to generate baseline data on CHIKV infection in northwest Ethiopia where malaria is endemic. Methods: A hospital-base...
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doaj-0f8d3a0e4a7a4c1b8ed22e4ac182e3912021-03-27T04:25:34ZengElsevierInternational Journal of Infectious Diseases1201-97122021-03-01104183188Evidence of chikungunya virus infection among febrile patients in northwest EthiopiaGetachew Ferede0Moges Tiruneh1Ebba Abate2Yitayih Wondimeneh3Endalamaw Gadisa4Rawleigh Howe5Abraham Aseffa6Belay Tessema7Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; Corresponding author.Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaArmauer Hansen Research Institute, Addis Ababa, EthiopiaArmauer Hansen Research Institute, Addis Ababa, EthiopiaArmauer Hansen Research Institute, Addis Ababa, EthiopiaDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaBackground: Chikungunya virus (CHIKV) infection has similar clinical presentations to malaria. Hence, febrile illnesses are often misdiagnosed as malaria. Therefore, this study aimed to generate baseline data on CHIKV infection in northwest Ethiopia where malaria is endemic. Methods: A hospital-based cross-sectional study was conducted among febrile patients presenting at the Metema and Humera Kahsay Abera hospitals from March 2016 to May 2017. Data on socio-demographic, clinical presentations, and possible risk factors were collected using a structured questionnaire. Serum samples were screened for immunoglobulin-M (IgM) and IgG antibodies to CHIKV infections using enzyme-linked immunosorbent assay. Logistic regression analysis was used to determine the strength of association. Results: Of 586 samples screened, the overall seroprevalence of CHIKV infection was 23%. Of the total study participants, 22.5% had CHIKV-specific IgM, indicating recent CHIKV infection. During monsoon and post-monsoon periods, increased prevalence of anti-CHIKV IgM seropositivity was found. The most common clinical presentation observed was fever, followed by headache and joint pain. Men had twice the likelihood of CHIKV infection. The presence of stagnant water near the residence almost doubled the risk for CHIKV infection. Conclusions: Most of the study participants had recent infection with CHIKV, suggesting the need to design disease prevention and intervention strategies.http://www.sciencedirect.com/science/article/pii/S1201971220325819Chikungunya virus infectionSeroprevalenceFebrile illnessNorthwest Ethiopia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Getachew Ferede Moges Tiruneh Ebba Abate Yitayih Wondimeneh Endalamaw Gadisa Rawleigh Howe Abraham Aseffa Belay Tessema |
spellingShingle |
Getachew Ferede Moges Tiruneh Ebba Abate Yitayih Wondimeneh Endalamaw Gadisa Rawleigh Howe Abraham Aseffa Belay Tessema Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia International Journal of Infectious Diseases Chikungunya virus infection Seroprevalence Febrile illness Northwest Ethiopia |
author_facet |
Getachew Ferede Moges Tiruneh Ebba Abate Yitayih Wondimeneh Endalamaw Gadisa Rawleigh Howe Abraham Aseffa Belay Tessema |
author_sort |
Getachew Ferede |
title |
Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia |
title_short |
Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia |
title_full |
Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia |
title_fullStr |
Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia |
title_full_unstemmed |
Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia |
title_sort |
evidence of chikungunya virus infection among febrile patients in northwest ethiopia |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-03-01 |
description |
Background: Chikungunya virus (CHIKV) infection has similar clinical presentations to malaria. Hence, febrile illnesses are often misdiagnosed as malaria. Therefore, this study aimed to generate baseline data on CHIKV infection in northwest Ethiopia where malaria is endemic. Methods: A hospital-based cross-sectional study was conducted among febrile patients presenting at the Metema and Humera Kahsay Abera hospitals from March 2016 to May 2017. Data on socio-demographic, clinical presentations, and possible risk factors were collected using a structured questionnaire. Serum samples were screened for immunoglobulin-M (IgM) and IgG antibodies to CHIKV infections using enzyme-linked immunosorbent assay. Logistic regression analysis was used to determine the strength of association. Results: Of 586 samples screened, the overall seroprevalence of CHIKV infection was 23%. Of the total study participants, 22.5% had CHIKV-specific IgM, indicating recent CHIKV infection. During monsoon and post-monsoon periods, increased prevalence of anti-CHIKV IgM seropositivity was found. The most common clinical presentation observed was fever, followed by headache and joint pain. Men had twice the likelihood of CHIKV infection. The presence of stagnant water near the residence almost doubled the risk for CHIKV infection. Conclusions: Most of the study participants had recent infection with CHIKV, suggesting the need to design disease prevention and intervention strategies. |
topic |
Chikungunya virus infection Seroprevalence Febrile illness Northwest Ethiopia |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220325819 |
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