An overview of cutaneous T cell lymphomas [version 1; referees: 2 approved]

• Main Authors: Nooshin Bagherani, Bruce R. Smoller
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2016-07-01
• Series: F1000Research
• Subjects: Cell Growth & Division; Cell Signaling; Cellular Death & Stress Responses; Control of Gene Expression; Cutaneous Signs of Systemic Disease; Developmental Molecular Mechanisms; Genetics of the Immune System; Immunopharmacology & Hematologic Pharmacology; Leukocyte Signaling & Gene Expression; Lymphomas & Myelomas; Medical Genetics; Photodermatology & Skin Aging; Stem Cells & Regeneration
• Online Access: http://f1000research.com/articles/5-1882/v1

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-Hodgkin’s lymphomas that are characterized by a cutaneous infiltration of malignant monoclonal T lymphocytes. They typically afflict adults with a median age of 55 to 60 years, and the annual incidence is about 0.5 per 100,000. Mycosis fungoides, Sézary syndrome, and primary cutaneous peripheral T cell lymphomas not otherwise specified are the most important subtypes of CTCL. CTCL is a complicated concept in terms of etiopathogenesis, diagnosis, therapy, and prognosis. Herein, we summarize advances which have been achieved in these fields.