The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy
Purpose: To investigate the clinical utility of transperineal template-guided saturation prostate biopsy (TPB) for risk stratification after transrectal ultrasound (TRUS)-guided biopsy. Materials and Methods: We retrospectively reviewed 155 patients who underwent TPB after previously negative result...
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Korean Urological Association
2019-11-01
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doaj-0f90d9f5c19a4b2398acb5093cb81d6a2020-11-24T21:56:55ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2019-11-0160645446210.4111/icu.2019.60.6.454The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsyWan Song0Minyong Kang1Byong Chang Jeong2Seong Il Seo3Seong Soo Jeon4Hyun Moo Lee5Hwang Gyun Jeon6Department of Urology, Ewha Womans University Medical Center, Ewha Womans University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Purpose: To investigate the clinical utility of transperineal template-guided saturation prostate biopsy (TPB) for risk stratification after transrectal ultrasound (TRUS)-guided biopsy. Materials and Methods: We retrospectively reviewed 155 patients who underwent TPB after previously negative results on TRUS-guided biopsy (n=58) or who were candidates for active surveillance (n=97) fulfilling the PRIAS criteria between May 2017 and November 2018. The patients' clinicopathologic data were reviewed, and the detection of clinically significant cancer (CSC) and upgrading of Gleason grade were identified. Results: The patients' median age and pre-TPB prostate-specific antigen (PSA) value were 65.0 years and 5.74 ng/mL, respectively. A median of 36 biopsy cores was obtained in each patient, with a median TPB core density of 0.88 cores/cm3. Of the 58 males with a previous negative result on TRUS-guided biopsy, prostate cancer (PCa) was detected in 17 males (29.3%), including 8 with CSC. Of the 97 patient candidates for active surveillance, upgrading of the Gleason grade was identified in 31 males (32.0%), 20 with a Gleason grade of 7 (3+4), 6 with a Gleason grade of 7 (4+3), and 5 with a Gleason grade of 8 (4+4). The overall complication rate was 14.8% (23/155), and there were no Clavien–Dindo grade 3 to 5 complications. Conclusions: TPB helps to stratify the risk of PCa that was previously missed or underdiagnosed by TRUS-guided biopsy. TPB might be used as a diagnostic tool to determine risk classification and to help counsel patients with regard to treatment decisions.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-454.pdfpsyprostatic neoplasmsriskwatchful waiting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wan Song Minyong Kang Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon |
spellingShingle |
Wan Song Minyong Kang Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy Investigative and Clinical Urology psy prostatic neoplasms risk watchful waiting |
author_facet |
Wan Song Minyong Kang Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon |
author_sort |
Wan Song |
title |
The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
title_short |
The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
title_full |
The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
title_fullStr |
The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
title_full_unstemmed |
The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
title_sort |
clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy |
publisher |
Korean Urological Association |
series |
Investigative and Clinical Urology |
issn |
2466-0493 2466-054X |
publishDate |
2019-11-01 |
description |
Purpose: To investigate the clinical utility of transperineal template-guided saturation prostate biopsy (TPB) for risk stratification after transrectal ultrasound (TRUS)-guided biopsy. Materials and Methods: We retrospectively reviewed 155 patients who underwent TPB after previously negative results on TRUS-guided biopsy (n=58) or who were candidates for active surveillance (n=97) fulfilling the PRIAS criteria between May 2017 and November 2018. The patients' clinicopathologic data were reviewed, and the detection of clinically significant cancer (CSC) and upgrading of Gleason grade were identified. Results: The patients' median age and pre-TPB prostate-specific antigen (PSA) value were 65.0 years and 5.74 ng/mL, respectively. A median of 36 biopsy cores was obtained in each patient, with a median TPB core density of 0.88 cores/cm3. Of the 58 males with a previous negative result on TRUS-guided biopsy, prostate cancer (PCa) was detected in 17 males (29.3%), including 8 with CSC. Of the 97 patient candidates for active surveillance, upgrading of the Gleason grade was identified in 31 males (32.0%), 20 with a Gleason grade of 7 (3+4), 6 with a Gleason grade of 7 (4+3), and 5 with a Gleason grade of 8 (4+4). The overall complication rate was 14.8% (23/155), and there were no Clavien–Dindo grade 3 to 5 complications. Conclusions: TPB helps to stratify the risk of PCa that was previously missed or underdiagnosed by TRUS-guided biopsy. TPB might be used as a diagnostic tool to determine risk classification and to help counsel patients with regard to treatment decisions. |
topic |
psy prostatic neoplasms risk watchful waiting |
url |
https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-454.pdf |
work_keys_str_mv |
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