Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors
Objectives. To investigate the usefulness of contrast-enhanced endoscopic ultrasonography (CE-EUS) for histological differentiation of pancreatic tumors. Methods. CE-EUS was performed for consecutive patients having a pancreatic solid lesion, and tumors were classified into three vascular patterns (...
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doaj-0fa64965ec154377be246061587b42722020-11-24T23:58:49ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/491782491782Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic TumorsYasunobu Yamashita0Jun Kato1Kazuki Ueda2Yasushi Nakamura3Yuki Kawaji4Hiroko Abe5Junya Nuta6Takashi Tamura7Masahiro Itonaga8Takeichi Yoshida9Hiroki Maeda10Takao Maekita11Mikitaka Iguchi12Hideyuki Tamai13Masao Ichinose14Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanDivision of Pathology, Department of Clinical Laboratory Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, JapanObjectives. To investigate the usefulness of contrast-enhanced endoscopic ultrasonography (CE-EUS) for histological differentiation of pancreatic tumors. Methods. CE-EUS was performed for consecutive patients having a pancreatic solid lesion, and tumors were classified into three vascular patterns (hypervascular, isovascular, and hypovascular) at two time phases (early-phase and late-phase). Correlation between vascular patterns and histopathology of resected pancreatic cancer (PC) tissues was ascertained. Results. The final diagnoses of 147 examined tumors were PC (n=109), inflammatory mass (n=11), autoimmune pancreatitis (n=9), neuroendocrine tumor (n=8), and others (n=10). In late-phase images, 104 of 109 PCs had the hypovascular pattern, for a diagnostic sensitivity and specificity of 94% and 71%, respectively. Of 28 resected PCs, 10 had isovascular, and 18 hypovascular, patterns on the early-phase image. Early-phase isovascular PCs were more likely to be differentiated than were early-phase hypovascular PCs (6 well and 4 moderately differentiated versus 3 well, 14 moderately, and 1 poorly differentiated, P=0.028). Immunostaining revealed that hypovascular areas of early-phase images reflected heterogeneous tumor cells with fibrous tissue, necrosis, and few vessels. Conclusion. CE-EUS could be useful for distinguishing PC from other solid pancreatic lesions and for histological differentiation of PCs.http://dx.doi.org/10.1155/2015/491782 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yasunobu Yamashita Jun Kato Kazuki Ueda Yasushi Nakamura Yuki Kawaji Hiroko Abe Junya Nuta Takashi Tamura Masahiro Itonaga Takeichi Yoshida Hiroki Maeda Takao Maekita Mikitaka Iguchi Hideyuki Tamai Masao Ichinose |
spellingShingle |
Yasunobu Yamashita Jun Kato Kazuki Ueda Yasushi Nakamura Yuki Kawaji Hiroko Abe Junya Nuta Takashi Tamura Masahiro Itonaga Takeichi Yoshida Hiroki Maeda Takao Maekita Mikitaka Iguchi Hideyuki Tamai Masao Ichinose Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors BioMed Research International |
author_facet |
Yasunobu Yamashita Jun Kato Kazuki Ueda Yasushi Nakamura Yuki Kawaji Hiroko Abe Junya Nuta Takashi Tamura Masahiro Itonaga Takeichi Yoshida Hiroki Maeda Takao Maekita Mikitaka Iguchi Hideyuki Tamai Masao Ichinose |
author_sort |
Yasunobu Yamashita |
title |
Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors |
title_short |
Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors |
title_full |
Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors |
title_fullStr |
Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors |
title_full_unstemmed |
Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors |
title_sort |
contrast-enhanced endoscopic ultrasonography for pancreatic tumors |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Objectives. To investigate the usefulness of contrast-enhanced endoscopic ultrasonography (CE-EUS) for histological differentiation of pancreatic tumors. Methods. CE-EUS was performed for consecutive patients having a pancreatic solid lesion, and tumors were classified into three vascular patterns (hypervascular, isovascular, and hypovascular) at two time phases (early-phase and late-phase). Correlation between vascular patterns and histopathology of resected pancreatic cancer (PC) tissues was ascertained. Results. The final diagnoses of 147 examined tumors were PC (n=109), inflammatory mass (n=11), autoimmune pancreatitis (n=9), neuroendocrine tumor (n=8), and others (n=10). In late-phase images, 104 of 109 PCs had the hypovascular pattern, for a diagnostic sensitivity and specificity of 94% and 71%, respectively. Of 28 resected PCs, 10 had isovascular, and 18 hypovascular, patterns on the early-phase image. Early-phase isovascular PCs were more likely to be differentiated than were early-phase hypovascular PCs (6 well and 4 moderately differentiated versus 3 well, 14 moderately, and 1 poorly differentiated, P=0.028). Immunostaining revealed that hypovascular areas of early-phase images reflected heterogeneous tumor cells with fibrous tissue, necrosis, and few vessels. Conclusion. CE-EUS could be useful for distinguishing PC from other solid pancreatic lesions and for histological differentiation of PCs. |
url |
http://dx.doi.org/10.1155/2015/491782 |
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