Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer
Cardiovascular disease risk is increased in survivors of testicular cancer because of exposure to treatment (chemotherapy and radiotherapy), as well as modification in lifestyle. Our aim was to assess the presence of subclinical arteriosclerosis in survivors of testicular cancer in comparison with a...
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doaj-0fa8d04bb6324527bb2a3f2c13bca1e02020-11-25T02:20:03ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-01997197110.3390/jcm9040971Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular CancerJavier Espíldora-Hernández0Tania Díaz-Antonio1Javier Baena-Espinar2Inmaculada Alonso-Calderón3José Rioja4Emilio Alba-Conejo5Pedro Valdivielso6Miguel-Ángel Sánchez-Chaparro7Internal Medicine Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainRadiology Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainOncology Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainPreventive Center for Civil Servant, Consejería de Empleo, 29010 Málaga, SpainLipid and Arteriosclerosis Laboratory, Department of Medicine and Dermatology, and Biomedical Institute for Research (IBIMA), Universidad de Málaga, 29010 Málaga, SpainOncology Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainInternal Medicine Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainInternal Medicine Unit, Hospital Virgen de la Victoria, 29010 Málaga, SpainCardiovascular disease risk is increased in survivors of testicular cancer because of exposure to treatment (chemotherapy and radiotherapy), as well as modification in lifestyle. Our aim was to assess the presence of subclinical arteriosclerosis in survivors of testicular cancer in comparison with a control group. This was a cross-sectional, observational, case–control study including 50 survivors of Germ Cell Tumor (GCT) (14 years of follow-up) and 53 age-matched controls with no cancer. We registered clinical data, cardiovascular risk factors, physical and Mediterranean questionnaires, intima-media thickness and plaque at carotid and femoral arteries by ultrasound, calcium score at the abdominal aorta, and liver steatosis by computed tomography, and applied analytical tests to quantify metabolic risk factors and inflammation markers. Patients showed a trend toward greater intima-media thickness (IMT) and plaques than controls, as well as a higher calcium score in the abdominal aorta. Remarkably, patients had higher waist circumference, insulin resistance (HOMA-IR), and liver steatosis, but lower physical activity and high-density lipoprotein (HDL) cholesterol than controls (all <i>p</i> < 0.05). In multivariate analyses, only common vascular risk factors were associated with subclinical arteriosclerosis. As a conclusion, in our study, a higher rate of subclinical arteriosclerosis in testicular cancer survivors was associated with classical metabolic risk factors and lifestyle, but not with exposure to chemotherapy.https://www.mdpi.com/2077-0383/9/4/971testicular cancersubclinical arteriosclerosisliver steatosisarterial ultrasoundvascular calcification |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Javier Espíldora-Hernández Tania Díaz-Antonio Javier Baena-Espinar Inmaculada Alonso-Calderón José Rioja Emilio Alba-Conejo Pedro Valdivielso Miguel-Ángel Sánchez-Chaparro |
spellingShingle |
Javier Espíldora-Hernández Tania Díaz-Antonio Javier Baena-Espinar Inmaculada Alonso-Calderón José Rioja Emilio Alba-Conejo Pedro Valdivielso Miguel-Ángel Sánchez-Chaparro Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer Journal of Clinical Medicine testicular cancer subclinical arteriosclerosis liver steatosis arterial ultrasound vascular calcification |
author_facet |
Javier Espíldora-Hernández Tania Díaz-Antonio Javier Baena-Espinar Inmaculada Alonso-Calderón José Rioja Emilio Alba-Conejo Pedro Valdivielso Miguel-Ángel Sánchez-Chaparro |
author_sort |
Javier Espíldora-Hernández |
title |
Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer |
title_short |
Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer |
title_full |
Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer |
title_fullStr |
Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer |
title_full_unstemmed |
Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer |
title_sort |
subclinical arteriosclerosis is associated with common vascular risk factors in long-term survivors of testicular cancer |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
Cardiovascular disease risk is increased in survivors of testicular cancer because of exposure to treatment (chemotherapy and radiotherapy), as well as modification in lifestyle. Our aim was to assess the presence of subclinical arteriosclerosis in survivors of testicular cancer in comparison with a control group. This was a cross-sectional, observational, case–control study including 50 survivors of Germ Cell Tumor (GCT) (14 years of follow-up) and 53 age-matched controls with no cancer. We registered clinical data, cardiovascular risk factors, physical and Mediterranean questionnaires, intima-media thickness and plaque at carotid and femoral arteries by ultrasound, calcium score at the abdominal aorta, and liver steatosis by computed tomography, and applied analytical tests to quantify metabolic risk factors and inflammation markers. Patients showed a trend toward greater intima-media thickness (IMT) and plaques than controls, as well as a higher calcium score in the abdominal aorta. Remarkably, patients had higher waist circumference, insulin resistance (HOMA-IR), and liver steatosis, but lower physical activity and high-density lipoprotein (HDL) cholesterol than controls (all <i>p</i> < 0.05). In multivariate analyses, only common vascular risk factors were associated with subclinical arteriosclerosis. As a conclusion, in our study, a higher rate of subclinical arteriosclerosis in testicular cancer survivors was associated with classical metabolic risk factors and lifestyle, but not with exposure to chemotherapy. |
topic |
testicular cancer subclinical arteriosclerosis liver steatosis arterial ultrasound vascular calcification |
url |
https://www.mdpi.com/2077-0383/9/4/971 |
work_keys_str_mv |
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