Phenotypic and Molecular Biological Analysis of Polymycovirus AfuPmV-1M From Aspergillus fumigatus: Reduced Fungal Virulence in a Mouse Infection Model

Phenotypic and Molecular Biological Analysis of Polymycovirus AfuPmV-1M From Aspergillus fumigatus: Reduced Fungal Virulence in a Mouse Infection Model

The filamentous fungal pathogen Aspergillus fumigatus is one of the most common causal agents of invasive fungal infection in humans; the infection is associated with an alarmingly high mortality rate. In this study, we investigated whether a mycovirus, named AfuPmV-1M, can reduce the virulence of A...

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Bibliographic Details
Main Authors: Azusa Takahashi-Nakaguchi, Erika Shishido, Misa Yahara, Syun-ichi Urayama, Akihiro Ninomiya, Yuto Chiba, Kanae Sakai, Daisuke Hagiwara, Hiroji Chibana, Hiromitsu Moriyama, Tohru Gonoi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
dsRNA
mycovirus
hypovirulence
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.607795/full

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