Retinal and choroidal angiogenesis: a review of new targets
Abstract Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient vision. The intraoc...
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doaj-0fad7f89d4ac4c959ef969af6cb7a3a82021-04-02T14:56:34ZengBMCInternational Journal of Retina and Vitreous2056-99202017-08-013111310.1186/s40942-017-0084-9Retinal and choroidal angiogenesis: a review of new targetsThiago Cabral0Luiz Guilherme M. Mello1Luiz H. Lima2Júlia Polido3Caio V. Regatieri4Rubens Belfort5Vinit B. Mahajan6Edward S Harkness Eye Institute, Columbia UniversityDepartment of Ophthalmology, Federal University of Espírito SantoDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Federal University of São PauloOmics Laboratory, Department of Ophthalmology, Byers Eye Institute, Stanford UniversityAbstract Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient vision. The intraocular use of anti-vascular endothelial growth factor therapeutics has improved management of the retinal and choroidal neovascularization but some patients do not respond, suggesting other vascular mediators may also contribute to ocular angiogenesis. Several recent studies examined possible new targets for future anti-angiogenic therapies. Potential targets of retinal and choroidal neovascularization therapy include members of the platelet-derived growth factor family, vascular endothelial growth factor sub-family, epidermal growth factor family, fibroblast growth factor family, transforming growth factor-β superfamily (TGF-β1, activins, follistatin and bone morphogenetic proteins), angiopoietin-like family, galectins family, integrin superfamily, as well as pigment epithelium derived factor, hepatocyte growth factor, angiopoietins, endothelins, hypoxia-inducible factors, insulin-like growth factors, cytokines, matrix metalloproteinases and their inhibitors and glycosylation proteins. This review highlights current antiangiogenic therapies under development, and discusses future retinal and choroidal pro- and anti-angiogenic targets as wells as the importance of developing of new drugs.http://link.springer.com/article/10.1186/s40942-017-0084-9Age-related macular degenerationAngiogenesisAnti-angiogenesisChoroidal neovascularizationCytokineOcular neovascularization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thiago Cabral Luiz Guilherme M. Mello Luiz H. Lima Júlia Polido Caio V. Regatieri Rubens Belfort Vinit B. Mahajan |
spellingShingle |
Thiago Cabral Luiz Guilherme M. Mello Luiz H. Lima Júlia Polido Caio V. Regatieri Rubens Belfort Vinit B. Mahajan Retinal and choroidal angiogenesis: a review of new targets International Journal of Retina and Vitreous Age-related macular degeneration Angiogenesis Anti-angiogenesis Choroidal neovascularization Cytokine Ocular neovascularization |
author_facet |
Thiago Cabral Luiz Guilherme M. Mello Luiz H. Lima Júlia Polido Caio V. Regatieri Rubens Belfort Vinit B. Mahajan |
author_sort |
Thiago Cabral |
title |
Retinal and choroidal angiogenesis: a review of new targets |
title_short |
Retinal and choroidal angiogenesis: a review of new targets |
title_full |
Retinal and choroidal angiogenesis: a review of new targets |
title_fullStr |
Retinal and choroidal angiogenesis: a review of new targets |
title_full_unstemmed |
Retinal and choroidal angiogenesis: a review of new targets |
title_sort |
retinal and choroidal angiogenesis: a review of new targets |
publisher |
BMC |
series |
International Journal of Retina and Vitreous |
issn |
2056-9920 |
publishDate |
2017-08-01 |
description |
Abstract Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient vision. The intraocular use of anti-vascular endothelial growth factor therapeutics has improved management of the retinal and choroidal neovascularization but some patients do not respond, suggesting other vascular mediators may also contribute to ocular angiogenesis. Several recent studies examined possible new targets for future anti-angiogenic therapies. Potential targets of retinal and choroidal neovascularization therapy include members of the platelet-derived growth factor family, vascular endothelial growth factor sub-family, epidermal growth factor family, fibroblast growth factor family, transforming growth factor-β superfamily (TGF-β1, activins, follistatin and bone morphogenetic proteins), angiopoietin-like family, galectins family, integrin superfamily, as well as pigment epithelium derived factor, hepatocyte growth factor, angiopoietins, endothelins, hypoxia-inducible factors, insulin-like growth factors, cytokines, matrix metalloproteinases and their inhibitors and glycosylation proteins. This review highlights current antiangiogenic therapies under development, and discusses future retinal and choroidal pro- and anti-angiogenic targets as wells as the importance of developing of new drugs. |
topic |
Age-related macular degeneration Angiogenesis Anti-angiogenesis Choroidal neovascularization Cytokine Ocular neovascularization |
url |
http://link.springer.com/article/10.1186/s40942-017-0084-9 |
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