Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury.
Accumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy of the antioxidants vitamin C and vitamin E in mou...
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2011-01-01
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doaj-0fb8ff869b86484ba9a634abbf6b6a0b2020-11-25T00:10:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01612e2924010.1371/journal.pone.0029240Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury.Ruirui LuWiebke Kallenborn-GerhardtGerd GeisslingerAchim SchmidtkoAccumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy of the antioxidants vitamin C and vitamin E in mouse models of inflammatory and neuropathic pain. We show that systemic administration of a combination of vitamins C and E inhibited the early behavioral responses to formalin injection and the neuropathic pain behavior after peripheral nerve injury, but not the inflammatory pain behavior induced by Complete Freund's Adjuvant. In contrast, vitamin C or vitamin E given alone failed to affect the nociceptive behavior in all tested models. The attenuated neuropathic pain behavior induced by the vitamin C and E combination was paralleled by a reduced p38 phosphorylation in the spinal cord and in dorsal root ganglia, and was also observed after intrathecal injection of the vitamins. Moreover, the vitamin C and E combination ameliorated the allodynia induced by an intrathecally delivered ROS donor. Our results suggest that administration of vitamins C and E in combination may exert synergistic antinociceptive effects, and further indicate that ROS essentially contribute to nociceptive processing in special pain states.http://europepmc.org/articles/PMC3237606?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruirui Lu Wiebke Kallenborn-Gerhardt Gerd Geisslinger Achim Schmidtko |
spellingShingle |
Ruirui Lu Wiebke Kallenborn-Gerhardt Gerd Geisslinger Achim Schmidtko Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. PLoS ONE |
author_facet |
Ruirui Lu Wiebke Kallenborn-Gerhardt Gerd Geisslinger Achim Schmidtko |
author_sort |
Ruirui Lu |
title |
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. |
title_short |
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. |
title_full |
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. |
title_fullStr |
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. |
title_full_unstemmed |
Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. |
title_sort |
additive antinociceptive effects of a combination of vitamin c and vitamin e after peripheral nerve injury. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Accumulating evidence indicates that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during persistent pain. In the present study, we investigated the antinociceptive efficacy of the antioxidants vitamin C and vitamin E in mouse models of inflammatory and neuropathic pain. We show that systemic administration of a combination of vitamins C and E inhibited the early behavioral responses to formalin injection and the neuropathic pain behavior after peripheral nerve injury, but not the inflammatory pain behavior induced by Complete Freund's Adjuvant. In contrast, vitamin C or vitamin E given alone failed to affect the nociceptive behavior in all tested models. The attenuated neuropathic pain behavior induced by the vitamin C and E combination was paralleled by a reduced p38 phosphorylation in the spinal cord and in dorsal root ganglia, and was also observed after intrathecal injection of the vitamins. Moreover, the vitamin C and E combination ameliorated the allodynia induced by an intrathecally delivered ROS donor. Our results suggest that administration of vitamins C and E in combination may exert synergistic antinociceptive effects, and further indicate that ROS essentially contribute to nociceptive processing in special pain states. |
url |
http://europepmc.org/articles/PMC3237606?pdf=render |
work_keys_str_mv |
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