Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats
Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, togethe...
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doaj-0fbba1e2c8a74a18943fd2746ab04c232020-11-24T21:24:27ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312013-12-0130436236810.5152/balkanmedj.2013.7785Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced RatsAhmet Rahmi Hatipoğlu0Muharrem Cidem1Tülin Yalta2Doğan Albayrak3Cengiz Erenoğlu4Tamer Sağıroğlu5Yavuz Atakan Sezer6Department of General Surgery, Trakya University Faculty of Medicine, Edirne, TurkeyDepartment of Physical Medicine and Rehabilitation, Bağcılar Training and Research Hospital, İstanbul, TurkeyDepartment of Pathology, Trakya University Faculty of Medicine, Edirne, TurkeyDepartment of General Surgery, Trakya University Faculty of Medicine, Edirne, TurkeyDepartment of General Surgery, Trakya University Faculty of Medicine, Edirne, TurkeyDepartment of General Surgery, Trakya University Faculty of Medicine, Edirne, TurkeyDepartment of General Surgery, Trakya University Faculty of Medicine, Edirne, TurkeyBackground: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design: Animal experimentation. Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.http://balkanmedicaljournal.org/text.php?lang=en&id=326Bacterial translocationglutaminetauroursodeoxycholic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahmet Rahmi Hatipoğlu Muharrem Cidem Tülin Yalta Doğan Albayrak Cengiz Erenoğlu Tamer Sağıroğlu Yavuz Atakan Sezer |
spellingShingle |
Ahmet Rahmi Hatipoğlu Muharrem Cidem Tülin Yalta Doğan Albayrak Cengiz Erenoğlu Tamer Sağıroğlu Yavuz Atakan Sezer Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats Balkan Medical Journal Bacterial translocation glutamine tauroursodeoxycholic acid |
author_facet |
Ahmet Rahmi Hatipoğlu Muharrem Cidem Tülin Yalta Doğan Albayrak Cengiz Erenoğlu Tamer Sağıroğlu Yavuz Atakan Sezer |
author_sort |
Ahmet Rahmi Hatipoğlu |
title |
Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats |
title_short |
Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats |
title_full |
Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats |
title_fullStr |
Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats |
title_full_unstemmed |
Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats |
title_sort |
combined effects of tauroursodeoxycholic acid and glutamine on bacterial translocation in obstructive jaundiced rats |
publisher |
Galenos Publishing House |
series |
Balkan Medical Journal |
issn |
2146-3123 2146-3131 |
publishDate |
2013-12-01 |
description |
Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced.
Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model.
Study Design: Animal experimentation.
Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day.
Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively).
Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features. |
topic |
Bacterial translocation glutamine tauroursodeoxycholic acid |
url |
http://balkanmedicaljournal.org/text.php?lang=en&id=326 |
work_keys_str_mv |
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