Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral...
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Bibliographic Details
Main Authors: |
Iria Carballo-Carbajal,
Ariadna Laguna,
Jordi Romero-Giménez,
Thais Cuadros,
Jordi Bové,
Marta Martinez-Vicente,
Annabelle Parent,
Marta Gonzalez-Sepulveda,
Núria Peñuelas,
Albert Torra,
Beatriz Rodríguez-Galván,
Andrea Ballabio,
Takafumi Hasegawa,
Analía Bortolozzi,
Ellen Gelpi,
Miquel Vila |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2019-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-08858-y
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