Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral...
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Nature Publishing Group
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08858-y |
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doaj-0fbc1ef6e5e046b1873667d6a11b3aa62021-05-11T12:10:09ZengNature Publishing GroupNature Communications2041-17232019-03-0110111910.1038/s41467-019-08858-yBrain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesisIria Carballo-Carbajal0Ariadna Laguna1Jordi Romero-Giménez2Thais Cuadros3Jordi Bové4Marta Martinez-Vicente5Annabelle Parent6Marta Gonzalez-Sepulveda7Núria Peñuelas8Albert Torra9Beatriz Rodríguez-Galván10Andrea Ballabio11Takafumi Hasegawa12Analía Bortolozzi13Ellen Gelpi14Miquel Vila15Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Telethon Institute of Genetics and Medicine (TIGEM)Department of Neurology, Tohoku University School of MedicineDepartment of Neurochemistry and Neuropharmacology, IIBB–CSIC, August Pi i Sunyer Biomedical Research Institute (IDIBAPS)-Center for Networked Biomedical Research on Mental Health (CIBERSAM)Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPSNeurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.https://doi.org/10.1038/s41467-019-08858-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila |
| spellingShingle |
Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis Nature Communications |
| author_facet |
Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila |
| author_sort |
Iria Carballo-Carbajal |
| title |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis |
| title_short |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis |
| title_full |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis |
| title_fullStr |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis |
| title_full_unstemmed |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis |
| title_sort |
brain tyrosinase overexpression implicates age-dependent neuromelanin production in parkinson’s disease pathogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-03-01 |
| description |
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold. |
| url |
https://doi.org/10.1038/s41467-019-08858-y |
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