Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral...

Full description

Bibliographic Details
Main Authors: Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08858-y
id doaj-0fbc1ef6e5e046b1873667d6a11b3aa6
record_format Article
spelling doaj-0fbc1ef6e5e046b1873667d6a11b3aa62021-05-11T12:10:09ZengNature Publishing GroupNature Communications2041-17232019-03-0110111910.1038/s41467-019-08858-yBrain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesisIria Carballo-Carbajal0Ariadna Laguna1Jordi Romero-Giménez2Thais Cuadros3Jordi Bové4Marta Martinez-Vicente5Annabelle Parent6Marta Gonzalez-Sepulveda7Núria Peñuelas8Albert Torra9Beatriz Rodríguez-Galván10Andrea Ballabio11Takafumi Hasegawa12Analía Bortolozzi13Ellen Gelpi14Miquel Vila15Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)Telethon Institute of Genetics and Medicine (TIGEM)Department of Neurology, Tohoku University School of MedicineDepartment of Neurochemistry and Neuropharmacology, IIBB–CSIC, August Pi i Sunyer Biomedical Research Institute (IDIBAPS)-Center for Networked Biomedical Research on Mental Health (CIBERSAM)Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPSNeurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.https://doi.org/10.1038/s41467-019-08858-y
collection DOAJ
language English
format Article
sources DOAJ
author Iria Carballo-Carbajal
Ariadna Laguna
Jordi Romero-Giménez
Thais Cuadros
Jordi Bové
Marta Martinez-Vicente
Annabelle Parent
Marta Gonzalez-Sepulveda
Núria Peñuelas
Albert Torra
Beatriz Rodríguez-Galván
Andrea Ballabio
Takafumi Hasegawa
Analía Bortolozzi
Ellen Gelpi
Miquel Vila
spellingShingle Iria Carballo-Carbajal
Ariadna Laguna
Jordi Romero-Giménez
Thais Cuadros
Jordi Bové
Marta Martinez-Vicente
Annabelle Parent
Marta Gonzalez-Sepulveda
Núria Peñuelas
Albert Torra
Beatriz Rodríguez-Galván
Andrea Ballabio
Takafumi Hasegawa
Analía Bortolozzi
Ellen Gelpi
Miquel Vila
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
Nature Communications
author_facet Iria Carballo-Carbajal
Ariadna Laguna
Jordi Romero-Giménez
Thais Cuadros
Jordi Bové
Marta Martinez-Vicente
Annabelle Parent
Marta Gonzalez-Sepulveda
Núria Peñuelas
Albert Torra
Beatriz Rodríguez-Galván
Andrea Ballabio
Takafumi Hasegawa
Analía Bortolozzi
Ellen Gelpi
Miquel Vila
author_sort Iria Carballo-Carbajal
title Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_short Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_full Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_fullStr Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_full_unstemmed Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_sort brain tyrosinase overexpression implicates age-dependent neuromelanin production in parkinson’s disease pathogenesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.
url https://doi.org/10.1038/s41467-019-08858-y
work_keys_str_mv AT iriacarballocarbajal braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT ariadnalaguna braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT jordiromerogimenez braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT thaiscuadros braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT jordibove braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT martamartinezvicente braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT annabelleparent braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT martagonzalezsepulveda braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT nuriapenuelas braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT alberttorra braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT beatrizrodriguezgalvan braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT andreaballabio braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT takafumihasegawa braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT analiabortolozzi braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT ellengelpi braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
AT miquelvila braintyrosinaseoverexpressionimplicatesagedependentneuromelaninproductioninparkinsonsdiseasepathogenesis
_version_ 1721445224859828224