Review: A review of the use of zonisamide in Parkinson’s disease
Although zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studies regarding its uses in other pathologies such as migraine,...
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2009-09-01
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Series: | Therapeutic Advances in Neurological Disorders |
Online Access: | https://doi.org/10.1177/1756285609338501 |
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doaj-0fcdf18af2b74eca994952ca242c2d342020-11-25T02:52:41ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28562009-09-01210.1177/1756285609338501Review: A review of the use of zonisamide in Parkinson’s diseasePedro Emilio BermejoBuenaventura AncionesAlthough zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studies regarding its uses in other pathologies such as migraine, neuropathic pain, essential tremor and various psychiatric diseases. A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan suggested that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson’s disease. In addition, other studies support the utility of zonisamide in other symptoms of this disease. The therapeutic doses of zonisamide for the treatment of Parkinson’s disease are considerably lower than those for the treatment of epilepsy. This antiepileptic drug has been used in Japan for more than 15 years and so it is expected that it will be safe and well tolerated in patients with Parkinson’s disease. However, the pharmacological mechanisms of the antiparkinsonian actions of zonisamide remain unclear and more basic investigation is warranted. The aim of this paper is to review the structure, mechanisms of action, pharmacokinetics and antiparkinsonian action of zonisamide.https://doi.org/10.1177/1756285609338501 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pedro Emilio Bermejo Buenaventura Anciones |
spellingShingle |
Pedro Emilio Bermejo Buenaventura Anciones Review: A review of the use of zonisamide in Parkinson’s disease Therapeutic Advances in Neurological Disorders |
author_facet |
Pedro Emilio Bermejo Buenaventura Anciones |
author_sort |
Pedro Emilio Bermejo |
title |
Review: A review of the use of zonisamide in Parkinson’s disease |
title_short |
Review: A review of the use of zonisamide in Parkinson’s disease |
title_full |
Review: A review of the use of zonisamide in Parkinson’s disease |
title_fullStr |
Review: A review of the use of zonisamide in Parkinson’s disease |
title_full_unstemmed |
Review: A review of the use of zonisamide in Parkinson’s disease |
title_sort |
review: a review of the use of zonisamide in parkinson’s disease |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Neurological Disorders |
issn |
1756-2856 |
publishDate |
2009-09-01 |
description |
Although zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studies regarding its uses in other pathologies such as migraine, neuropathic pain, essential tremor and various psychiatric diseases. A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan suggested that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson’s disease. In addition, other studies support the utility of zonisamide in other symptoms of this disease. The therapeutic doses of zonisamide for the treatment of Parkinson’s disease are considerably lower than those for the treatment of epilepsy. This antiepileptic drug has been used in Japan for more than 15 years and so it is expected that it will be safe and well tolerated in patients with Parkinson’s disease. However, the pharmacological mechanisms of the antiparkinsonian actions of zonisamide remain unclear and more basic investigation is warranted. The aim of this paper is to review the structure, mechanisms of action, pharmacokinetics and antiparkinsonian action of zonisamide. |
url |
https://doi.org/10.1177/1756285609338501 |
work_keys_str_mv |
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