Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging.
Biorhythm is a fundamental property of human physiology. Changes in the extracellular space induced by cell swelling in response to the neural activity enable the in vivo characterization of cerebral microstructure by measuring the water diffusivity using diffusion tensor imaging (DTI). To study the...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3882241?pdf=render |
id |
doaj-0fdbb66acc7242cdb4aa44f2a900b6bb |
---|---|
record_format |
Article |
spelling |
doaj-0fdbb66acc7242cdb4aa44f2a900b6bb2020-11-25T02:15:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8482210.1371/journal.pone.0084822Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging.Chunxiang JiangLijuan ZhangChao ZouXiaojing LongXin LiuHairong ZhengWeiqi LiaoYanjun DiaoBiorhythm is a fundamental property of human physiology. Changes in the extracellular space induced by cell swelling in response to the neural activity enable the in vivo characterization of cerebral microstructure by measuring the water diffusivity using diffusion tensor imaging (DTI). To study the diurnal microstructural alterations of human brain, fifteen right-handed healthy adult subjects were recruited for DTI studies in two repeated sessions (8∶30 AM and 8∶30 PM) within a 24-hour interval. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial (λ//) and radial diffusivity (λ⊥) were compared pixel by pixel between the sessions for each subject. Significant increased morning measurements in FA, ADC, λ// and λ⊥ were seen in a wide range of brain areas involving frontal, parietal, temporal and occipital lobes. Prominent evening dominant λ⊥ (18.58%) was detected in the right inferior temporal and ventral fusiform gyri. AM-PM variation of λ⊥ was substantially left side hemisphere dominant (p<0.05), while no hemispheric preference was observed for the same analysis for ADC (p = 0.77), λ// (p = 0.08) or FA (p = 0.25). The percentage change of ADC, λ//, λ⊥, and FA were 1.59%, 2.15%, 1.20% and 2.84%, respectively, for brain areas without diurnal diffusivity contrast. Microstructural variations may function as the substrates of the phasic neural activities in correspondence to the environment adaptation in a light-dark cycle. This research provided a baseline for researches in neuroscience, sleep medicine, psychological and psychiatric disorders, and necessitates that diurnal effect should be taken into account in following up studies using diffusion tensor quantities.http://europepmc.org/articles/PMC3882241?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chunxiang Jiang Lijuan Zhang Chao Zou Xiaojing Long Xin Liu Hairong Zheng Weiqi Liao Yanjun Diao |
spellingShingle |
Chunxiang Jiang Lijuan Zhang Chao Zou Xiaojing Long Xin Liu Hairong Zheng Weiqi Liao Yanjun Diao Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. PLoS ONE |
author_facet |
Chunxiang Jiang Lijuan Zhang Chao Zou Xiaojing Long Xin Liu Hairong Zheng Weiqi Liao Yanjun Diao |
author_sort |
Chunxiang Jiang |
title |
Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
title_short |
Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
title_full |
Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
title_fullStr |
Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
title_full_unstemmed |
Diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
title_sort |
diurnal microstructural variations in healthy adult brain revealed by diffusion tensor imaging. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Biorhythm is a fundamental property of human physiology. Changes in the extracellular space induced by cell swelling in response to the neural activity enable the in vivo characterization of cerebral microstructure by measuring the water diffusivity using diffusion tensor imaging (DTI). To study the diurnal microstructural alterations of human brain, fifteen right-handed healthy adult subjects were recruited for DTI studies in two repeated sessions (8∶30 AM and 8∶30 PM) within a 24-hour interval. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial (λ//) and radial diffusivity (λ⊥) were compared pixel by pixel between the sessions for each subject. Significant increased morning measurements in FA, ADC, λ// and λ⊥ were seen in a wide range of brain areas involving frontal, parietal, temporal and occipital lobes. Prominent evening dominant λ⊥ (18.58%) was detected in the right inferior temporal and ventral fusiform gyri. AM-PM variation of λ⊥ was substantially left side hemisphere dominant (p<0.05), while no hemispheric preference was observed for the same analysis for ADC (p = 0.77), λ// (p = 0.08) or FA (p = 0.25). The percentage change of ADC, λ//, λ⊥, and FA were 1.59%, 2.15%, 1.20% and 2.84%, respectively, for brain areas without diurnal diffusivity contrast. Microstructural variations may function as the substrates of the phasic neural activities in correspondence to the environment adaptation in a light-dark cycle. This research provided a baseline for researches in neuroscience, sleep medicine, psychological and psychiatric disorders, and necessitates that diurnal effect should be taken into account in following up studies using diffusion tensor quantities. |
url |
http://europepmc.org/articles/PMC3882241?pdf=render |
work_keys_str_mv |
AT chunxiangjiang diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT lijuanzhang diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT chaozou diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT xiaojinglong diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT xinliu diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT hairongzheng diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT weiqiliao diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging AT yanjundiao diurnalmicrostructuralvariationsinhealthyadultbrainrevealedbydiffusiontensorimaging |
_version_ |
1724895802157957120 |