Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans
Chiral nonracemic aminobenzylnaphthols were obtained by a Betti multi-component reaction between 2-naphthol, aryl aldehydes and enantiopure arylethylamine. Moreover, some new aminobenzylnaphthols were synthesized by a similar reaction between 2-naphthol, aryl aldehydes and prolinol. These aminobenzy...
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doaj-0fe790a629d54da79734faa2e13228eb2020-11-24T23:58:48ZengMDPI AGMolecules1420-30492014-04-011945219523010.3390/molecules19045219molecules19045219Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicansMaria Annunziata M. Capozzi0Cosimo Cardellicchio1Angela Magaletti2Antonio Bevilacqua3Marianne Perricone4Maria Rosaria Corbo5Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, ItalyCNR-ICCOM, at the Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, ItalyDepartment of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, ItalyDepartment of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, ItalyDepartment of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, ItalyDepartment of the Science of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, ItalyChiral nonracemic aminobenzylnaphthols were obtained by a Betti multi-component reaction between 2-naphthol, aryl aldehydes and enantiopure arylethylamine. Moreover, some new aminobenzylnaphthols were synthesized by a similar reaction between 2-naphthol, aryl aldehydes and prolinol. These aminobenzylnaphthols, synthesized from different components and thus having different structural features, were tested as anti-yeast agents inhibiting Candida albicans. The effect towards the test strain was studied with a microdilution approach and three different concentrations (150, 300 and 450 µg/mL) were tested. The best results were found for the aminobenzylnaphthols obtained from 1-naphthylethylamine and from natural prolinol. The use of the two-way ANOVA highlighted the better performances of the prolinol derivative among the differently structured aminobenzylnaphthols that were screened. The activity towards C. albicans of this prolinol derivative resulted to be interesting and could represent a promising alternative to overcome the problem of the strains resistant to the traditional antifungals.http://www.mdpi.com/1420-3049/19/4/5219Candida albicansBetti reactionprolinolanti-yeast activitymicrodilution approachinteractive effects |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Annunziata M. Capozzi Cosimo Cardellicchio Angela Magaletti Antonio Bevilacqua Marianne Perricone Maria Rosaria Corbo |
spellingShingle |
Maria Annunziata M. Capozzi Cosimo Cardellicchio Angela Magaletti Antonio Bevilacqua Marianne Perricone Maria Rosaria Corbo Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans Molecules Candida albicans Betti reaction prolinol anti-yeast activity microdilution approach interactive effects |
author_facet |
Maria Annunziata M. Capozzi Cosimo Cardellicchio Angela Magaletti Antonio Bevilacqua Marianne Perricone Maria Rosaria Corbo |
author_sort |
Maria Annunziata M. Capozzi |
title |
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans |
title_short |
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans |
title_full |
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans |
title_fullStr |
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans |
title_full_unstemmed |
Bioactivity of a Family of Chiral Nonracemic Aminobenzylnaphthols towards Candida albicans |
title_sort |
bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards candida albicans |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-04-01 |
description |
Chiral nonracemic aminobenzylnaphthols were obtained by a Betti multi-component reaction between 2-naphthol, aryl aldehydes and enantiopure arylethylamine. Moreover, some new aminobenzylnaphthols were synthesized by a similar reaction between 2-naphthol, aryl aldehydes and prolinol. These aminobenzylnaphthols, synthesized from different components and thus having different structural features, were tested as anti-yeast agents inhibiting Candida albicans. The effect towards the test strain was studied with a microdilution approach and three different concentrations (150, 300 and 450 µg/mL) were tested. The best results were found for the aminobenzylnaphthols obtained from 1-naphthylethylamine and from natural prolinol. The use of the two-way ANOVA highlighted the better performances of the prolinol derivative among the differently structured aminobenzylnaphthols that were screened. The activity towards C. albicans of this prolinol derivative resulted to be interesting and could represent a promising alternative to overcome the problem of the strains resistant to the traditional antifungals. |
topic |
Candida albicans Betti reaction prolinol anti-yeast activity microdilution approach interactive effects |
url |
http://www.mdpi.com/1420-3049/19/4/5219 |
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