Cell-based glycan arrays for probing glycan–glycan binding protein interactions

Glycans, interaction platforms protruding from the surface of cells, are hard to study due to their diverse architecture. Here, the authors present a method to obtain cells carrying defined glycans, which can then be used to find proteins specifically recognizing these tags.

Bibliographic Details
Main Authors: Jennie Grace Briard, Hao Jiang, Kelley W. Moremen, Matthew Scott Macauley, Peng Wu
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03245-5
Description
Summary:Glycans, interaction platforms protruding from the surface of cells, are hard to study due to their diverse architecture. Here, the authors present a method to obtain cells carrying defined glycans, which can then be used to find proteins specifically recognizing these tags.
ISSN:2041-1723