Probiotics to prevent Staphylococcus aureus disease?

• Main Authors: Pipat Piewngam, Michael Otto
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2020-01-01
• Series: Gut Microbes
• Subjects: staphylococcus aureus; bacillus subtilis; quorum-sensing; probiotics; colonization resistance
• Online Access: http://dx.doi.org/10.1080/19490976.2019.1591137

There are a plethora of probiotic formulae that supposedly benefit human health on the market. However, the scientific underpinnings of the claimed benefits have remained poorly established. Scientific evidence is now increasingly being provided that explains those benefits, for example, by immune-stimulatory effects or inter-bacterial competition between beneficial and pathogenic bacteria. In our recent study (Piewngam et al. Nature 2018), we show that Bacillus colonization of the human intestine is negatively correlated with that of the human pathogen, Staphylococcus aureus. This type of colonization resistance is achieved by secretion of a class of lipopeptides by Bacillus species that inhibits S. aureus quorum-sensing signaling, which we found is crucial for S. aureus intestinal colonization. Here, we discuss what these findings imply for the general role of S. aureus intestinal colonization, the role of quorum-sensing in that process, and potential alternative ways to control S. aureus infection.