Summary: | The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni<sub>3</sub>(abb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>1</b>), [Ni<sub>3</sub>(tebb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub>·H<sub>2</sub>O (<b>2</b>), and [Ni<sub>3</sub>(pmdien)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>3</b>), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH<sub>3</sub> = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex <b>3</b> was investigated. All the complexes show antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> to different extents. The cytotoxic activity of complex <b>3</b> and ttcNa<sub>3</sub> were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex <b>3</b> possesses the cytotoxic activity against the tested cell lines, whereas ttcNa<sub>3</sub> did not show any cytotoxic activity.
|