An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni3(abb)3(H2O)3(µ-ttc)](ClO4)3 (1), [Ni3(tebb)&...

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Main Authors:	Amir M. Ashrafi, Pavel Kopel, Lukas Richtera
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Materials
Subjects:	nickel complexes trithiocyanuric acid trimercaptotriazine cyclic voltammetry
Online Access:	https://www.mdpi.com/1996-1944/13/7/1782

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spelling	doaj-100f1925c0724ceda8337a40cc73eccf2020-11-25T02:28:53ZengMDPI AGMaterials1996-19442020-04-01131782178210.3390/ma13071782An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate ComplexesAmir M. Ashrafi0Pavel Kopel1Lukas Richtera2Faculty of Electrical Engineering and Communication, Department of Microelectronics, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech RepublicFaculty of Electrical Engineering and Communication, Department of Microelectronics, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech RepublicFaculty of Electrical Engineering and Communication, Department of Microelectronics, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech RepublicThe electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni<sub>3</sub>(abb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>1</b>), [Ni<sub>3</sub>(tebb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub>·H<sub>2</sub>O (<b>2</b>), and [Ni<sub>3</sub>(pmdien)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>3</b>), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH<sub>3</sub> = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex <b>3</b> was investigated. All the complexes show antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> to different extents. The cytotoxic activity of complex <b>3</b> and ttcNa<sub>3</sub> were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex <b>3</b> possesses the cytotoxic activity against the tested cell lines, whereas ttcNa<sub>3</sub> did not show any cytotoxic activity.https://www.mdpi.com/1996-1944/13/7/1782nickel complexestrithiocyanuric acidtrimercaptotriazinecyclic voltammetry
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amir M. Ashrafi Pavel Kopel Lukas Richtera
spellingShingle	Amir M. Ashrafi Pavel Kopel Lukas Richtera An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes Materials nickel complexes trithiocyanuric acid trimercaptotriazine cyclic voltammetry
author_facet	Amir M. Ashrafi Pavel Kopel Lukas Richtera
author_sort	Amir M. Ashrafi
title	An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes
title_short	An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes
title_full	An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes
title_fullStr	An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes
title_full_unstemmed	An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes
title_sort	investigation on the electrochemical behavior and antibacterial and cytotoxic activity of nickel trithiocyanurate complexes
publisher	MDPI AG
series	Materials
issn	1996-1944
publishDate	2020-04-01
description	The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni<sub>3</sub>(abb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>1</b>), [Ni<sub>3</sub>(tebb)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub>·H<sub>2</sub>O (<b>2</b>), and [Ni<sub>3</sub>(pmdien)<sub>3</sub>(µ-ttc)](ClO<sub>4</sub>)<sub>3</sub> (<b>3</b>), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH<sub>3</sub> = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex <b>3</b> was investigated. All the complexes show antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> to different extents. The cytotoxic activity of complex <b>3</b> and ttcNa<sub>3</sub> were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex <b>3</b> possesses the cytotoxic activity against the tested cell lines, whereas ttcNa<sub>3</sub> did not show any cytotoxic activity.
topic	nickel complexes trithiocyanuric acid trimercaptotriazine cyclic voltammetry
url	https://www.mdpi.com/1996-1944/13/7/1782
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An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

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