Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics
Inflammatory biomarkers provide a minimally invasive means for early detection and specific treatment of metabolic syndrome and related disorders. The objective of this work was to search for inflammatory biomarkers of cardiometabolic risk in obese type 2 diabetics. The study was performed on 165 pe...
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doaj-101446617bb240f8a5fe3e91bec2e1ad2020-11-24T20:49:02ZengMDPI AGMedical Sciences2076-32712017-11-01542510.3390/medsci5040025medsci5040025Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 DiabeticsLamiaa A. A. Barakat0Hassan A. Shora1Ibrahim M. El-Deen2El-Sayed Abd El-Sameeh El-Sayed3Biochemistry Department, Faculty of Science, Port Said University, Port Said 065, EgyptInternal Medicine Department, Ismailia General Hospital, Ismailia 064, EgyptBiochemistry Department, Faculty of Science, Port Said University, Port Said 065, EgyptBiochemistry Department, Faculty of Science, Port Said University, Port Said 065, EgyptInflammatory biomarkers provide a minimally invasive means for early detection and specific treatment of metabolic syndrome and related disorders. The objective of this work was to search for inflammatory biomarkers of cardiometabolic risk in obese type 2 diabetics. The study was performed on 165 persons attending the medical outpatient clinic of Ismailia General Hospital. Their mean age was (50.69 ± 10.15) years. They were divided into three groups. The control group was composed of 55 non-obese, non-diabetic healthy volunteers, 32 males and 23 females. Two study groups were included in this study: group 2 was composed of 55 obese, non-diabetic subjects, 25 males and 30 females matched for age and gender. All patients including the control were subjected to clinical history taking, a clinical examination for the measurement of body mass index (BMI). Investigations were carried out for fasting blood glucose, fasting serum insulin, insulin resistance (IR), the lipid profile, lipoprotein band lipoprotein phospholipase A2, and non-high-density lipoprotein cholesterol (non-HDL-C). Urea, albumin and creatinine analysis and liver function tests were performed, and a complete blood count (CBC) was taken. Hemoglobin A1C (HbA1C), serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were tested. There were statistically significant differences among the studied groups in terms of total cholesterol, non-HDL-C, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipase A2 and apolipoprotein B. The inflammatory biomarkers hs-CRP, IL-6 and TNF-α were significantly statistically increased in the study groups by (1.62 ± 0.99, 2.32 ± 1.11), (1.73 ± 1.14, 2.53 ± 1.34), and (1.87 ± 1.09, 2.17 ± 0.89) respectively, where p < 0.01. Significant positive correlation was found between Homeostatic Model Assessment (HOMA)-IR, hs-CRP and IL-6. There was a significant positive correlation between non-HDL and hs-CRP, IL-6 and TNF-α and triglycerides and hs-CRP. In conclusion, in this study, CRP, IL-6, and TNF-α were significantly elevated in obese Egyptian type 2 diabetics and were positively correlated with insulin resistance, non-HDL and triglycerides. These inflammatory biomarkers could help in the premature identification of obese type 2 diabetic patients at high cardiometabolic risk. Additionally, these biomarkers are critical for providing prognostics and the validity of future potential anti-inflammatory therapeutic modalities.https://www.mdpi.com/2076-3271/5/4/25inflammatory biomarkersobese type 2 diabeticscardiometabolic riskinsulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lamiaa A. A. Barakat Hassan A. Shora Ibrahim M. El-Deen El-Sayed Abd El-Sameeh El-Sayed |
spellingShingle |
Lamiaa A. A. Barakat Hassan A. Shora Ibrahim M. El-Deen El-Sayed Abd El-Sameeh El-Sayed Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics Medical Sciences inflammatory biomarkers obese type 2 diabetics cardiometabolic risk insulin resistance |
author_facet |
Lamiaa A. A. Barakat Hassan A. Shora Ibrahim M. El-Deen El-Sayed Abd El-Sameeh El-Sayed |
author_sort |
Lamiaa A. A. Barakat |
title |
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics |
title_short |
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics |
title_full |
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics |
title_fullStr |
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics |
title_full_unstemmed |
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics |
title_sort |
inflammatory biomarkers of cardiometabolic risk in obese egyptian type 2 diabetics |
publisher |
MDPI AG |
series |
Medical Sciences |
issn |
2076-3271 |
publishDate |
2017-11-01 |
description |
Inflammatory biomarkers provide a minimally invasive means for early detection and specific treatment of metabolic syndrome and related disorders. The objective of this work was to search for inflammatory biomarkers of cardiometabolic risk in obese type 2 diabetics. The study was performed on 165 persons attending the medical outpatient clinic of Ismailia General Hospital. Their mean age was (50.69 ± 10.15) years. They were divided into three groups. The control group was composed of 55 non-obese, non-diabetic healthy volunteers, 32 males and 23 females. Two study groups were included in this study: group 2 was composed of 55 obese, non-diabetic subjects, 25 males and 30 females matched for age and gender. All patients including the control were subjected to clinical history taking, a clinical examination for the measurement of body mass index (BMI). Investigations were carried out for fasting blood glucose, fasting serum insulin, insulin resistance (IR), the lipid profile, lipoprotein band lipoprotein phospholipase A2, and non-high-density lipoprotein cholesterol (non-HDL-C). Urea, albumin and creatinine analysis and liver function tests were performed, and a complete blood count (CBC) was taken. Hemoglobin A1C (HbA1C), serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were tested. There were statistically significant differences among the studied groups in terms of total cholesterol, non-HDL-C, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipase A2 and apolipoprotein B. The inflammatory biomarkers hs-CRP, IL-6 and TNF-α were significantly statistically increased in the study groups by (1.62 ± 0.99, 2.32 ± 1.11), (1.73 ± 1.14, 2.53 ± 1.34), and (1.87 ± 1.09, 2.17 ± 0.89) respectively, where p < 0.01. Significant positive correlation was found between Homeostatic Model Assessment (HOMA)-IR, hs-CRP and IL-6. There was a significant positive correlation between non-HDL and hs-CRP, IL-6 and TNF-α and triglycerides and hs-CRP. In conclusion, in this study, CRP, IL-6, and TNF-α were significantly elevated in obese Egyptian type 2 diabetics and were positively correlated with insulin resistance, non-HDL and triglycerides. These inflammatory biomarkers could help in the premature identification of obese type 2 diabetic patients at high cardiometabolic risk. Additionally, these biomarkers are critical for providing prognostics and the validity of future potential anti-inflammatory therapeutic modalities. |
topic |
inflammatory biomarkers obese type 2 diabetics cardiometabolic risk insulin resistance |
url |
https://www.mdpi.com/2076-3271/5/4/25 |
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